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Prof. Dr. Serge Haan
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| Fakultät oder Zentrum | Fakultät für Naturwissenschaften, Technologie und Medizin | ||||
| Department | Fachbereich Lebenswissenschaften und Medizin | ||||
| Postadresse |
Université du Luxembourg Maison du Savoir 2, Avenue de l'Université L-4365 Esch-sur-Alzette |
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| Büroadresse | MSA, E16 1625-110 | ||||
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| Telefon | (+352) 46 66 44 6437 | ||||
- Vice-dean of the Faculty of Science, Technology and Communication
- Head of the Molecular Disease Mechanisms Group
- Professor of Biological chemistry
Last updated on: Freitag, den 11. Oktober 2019
2020
Prognostic and Predictive Molecular Biomarkers for Colorectal Cancer: Updates and Challenges; ; ;
in Cancers (2020)
Understanding the role of Fusobacterium nucleatum metabolism in colon cancer initiation and progression; ; ; ; ; ; ; ; ; ; ;
Poster (2020, February 22)
Microbiome in Colorectal Cancer: How to Getfrom Meta-omics to Mechanism?; ; ; ; ;
in Trends in Microbiology (2020)
2019
Integrated In Vitro and In Silico Modeling Delineates the Molecular Effects of a Synbiotic Regimen on Colorectal-Cancer-Derived Cells; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Cell Reports (2019), 27
In search of definitions: Cancer-associated fibroblasts and their markers; ; ; ;
in International Journal of Cancer (2019)
Identifying and targeting cancer-specific metabolism with network-based drug target prediction; ; ; ; ; ;
in EBioMedicine (2019), 43(May 2019), 98-106
Hypoxia-induced Autophagy Drives Colorectal Cancer Initiation and Progression by Activating the PRKC/PKC-EZR (Ezrin) Pathway; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Autophagy (2019)
Hypoxia- and MicroRNA-Induced Metabolic Reprogramming of Tumor-Initiating Cells; ; ; ;
in Cells (2019), 8(6),
Tumor suppressor miR-215 counteracts hypoxia-induced colon cancer stem cell activity; ; ; ; ; ; ; ; ; ; ;
in Cancer Letters (2019), 450
2018
Cominatorial effect of dietary fibre and Lactobacillus rhamnosus in the context of colorectal cancer therapy; ; ; ; ; ; ; ; ; ;
Poster (2018, February 16)
The PD-L1- and IL6-mediated dampening of the IL27/STAT1 anticancer responses are prevented by a-PD-L1 or a-IL6 antibodies; ; ; ; ; ; ; ; ; ; ; ; ;
in Journal of Leukocyte Biology (2018), 104
The microRNA-371~373 cluster represses colon cancer initiation and metastatic colonization by inhibiting the TGFBR2/ID1 signaling axis.; ; ; ; ; ; ; ; ; ; ; ;
in Cancer research (2018)
2017
Insights into ligand stimulation effects on gastro-intestinal stromal tumors signalling.; ; ; ; ; ;
in Cell Signal (2017)
Tumor-Initiating Cells: a criTICal review of isolation approaches and new challenges in targeting strategies; ; ;
in Molecular Cancer (2017)
Loss of Myosin Vb in colorectal cancer is a strong prognostic factor for disease recurrence; ; ; ; ; ; ; ;
in British Journal of Cancer (2017), 117(11), 1689-1701
Crosstalk between different family members: IL27 recapitulates IFNγ responses in HCC cells, but is inhibited by IL6-type cytokines; ; ; ; ; ; ; ; ; ; ;
in BBA Molecular Cell Research (2017)
From meta-genomics to causality: Understanding the role of colon cancer-associated bacteria in colorectal cancer; ; ;
Poster (2017, February 05)
2016
Data on quantification of signaling pathways activated by KIT and PDGFRA mutants.; ; ; ; ; ;
in Data in Brief (2016), (9), 828-838
What Do We Learn from Spheroid Culture Systems? Insights from Tumorspheres Derived from Primary Colon Cancer Tissue.; ; ; ; ; ;
in PLoS ONE (2016), 11
A study of the molecular mechanisms underlying the response of human colorectal adenomacarcinoma enterocytes to prebiotics and probiotics; ; ; ; ; ; ; ; ; ;
Poster (2016, June)
SOCS2: physiological and pathological functions.;
in Frontiers in Bioscience (Elite Edition) (2016), 8
Dissecting functions of the N-terminal domain and GAS-site recognition in STAT3; ; ; ; ;
in Cellular Signalling (2016), 28(8), 810-25
A Probabilistic Boolean Network Approach for the Analysis of Cancer-Specific Signalling: A Case Study of Deregulated PDGF Signalling in GIST.; ; ; ;
in PloS one (2016), 11(5), 0156223
Hypoxia-responsive miR-210 promotes self-renewal capacity of colon tumor-initiating cells by repressing ISCU and by inducing lactate production; ; ; ; ; ; ; ; ; ; ;
in Oncotarget (2016), 7(40), 97-114
2015
Constitutive activation of oncogenic PDGFRalpha-mutant proteins occurring in GIST patients induces receptor mislocalisation and alters PDGFRalpha signalling characteristics.; ; ; ; ; ; ; ; ; ; ;
in Cell Communication and Signaling (2015), 13
The oncogenic FIP1L1-PDGFRalpha fusion protein displays skewed signaling properties compared to its wild-type PDGFRalpha counterpart.; ; ; ; ; ; ; ; ; ; ;
in JAK-STAT (2015), 4(1), 1062596
2014
Kapitel 35: Rezeptoren und ihre Signaltransduktion; ; ; ;
in Heinrich, Peter C.; Müller, Matthias; Graeve, Lutz (Eds.) Biochemie und Pathobiochemie (2014)
Kapitel 34: Mediatoren; ; ; ;
in Heinrich, Peter C.; Müller, Matthias; Graeve, Lutz (Eds.) Biochemie und Pathobiochemie (2014)
Identification of SOCS2 and SOCS6 as biomarkers in human colorectal cancer.; ; ; ; ; ; ; ; ; ; ;
in British journal of cancer (2014), 111(4), 726-35
2013
Co-immunoprecipitation protocol to investigate cytokine receptor-associated proteins, e.g., Janus kinases or other associated signaling proteins.;
in Methods in Molecular Biology (Clifton, N.J.) (2013), 967
Detection of activated STAT species using electrophoretic mobility shift assay (EMSA) and potential pitfalls arising from the use of detergents.;
in Methods in Molecular Biology (Clifton, N.J.) (2013), 967
JAK2-V617F-induced MAPK activity is regulated by PI3K and acts synergistically with PI3K on the proliferation of JAK2-V617F-positive cells.; ; ; ; ; ; ; ;
in JAK-STAT (2013), 2(3), 24574
2012
Regulation of JAKs: Insights gleaned from the functional protein domains; ; ; ;
in Decker, Thomas; Müller, Mathias (Eds.) JAK-STAT Signaling – From Basics to Disease (2012)
2010
Perspectives for the use of structural information and chemical genetics to develop inhibitors of Janus kinases.; ;
in Journal of Cellular and Molecular Medicine (2010), 14(3), 504-27
Interleukin-27 acts on hepatic stellate cells and induces signal transducer and activator of transcription 1-dependent responses.; ;
in Cell Communication and Signaling (2010), 8
2009
Interleukin-27 displays interferon-gamma-like functions in human hepatoma cells and hepatocytes.; ; ; ; ; ; ; ; ;
in Hepatology (2009), 50(2), 585-91
An unusual insertion in Jak2 is crucial for kinase activity and differentially affects cytokine responses; ; ; ; ; ; ; ;
in Journal of Immunology (2009), 182(5), 2969-2977
SOCS-mediated downregulation of mutant Jak2 (V617F, T875N and K539L) counteracts cytokine-independent signaling.; ; ; ; ; ;
in Oncogene (2009), 28(34), 3069-80
Development of an IL-6 inhibitor based on the functional analysis of murine IL-6Ralpha(1).; ; ; ; ; ; ;
in Chemistry and Biology (2009), 16(7), 783-94
2008
Dual role of the Jak1 FERM and kinase domains in cytokine receptor binding and in stimulation-dependent Jak activation; ; ; ; ; ; ;
in Journal of Immunology (2008), 180(2), 998-1007
Cell density dependent increase of constitutive signal transducers and activators of transcription 3 activity in melanoma cells is mediated by Janus kinases; ; ; ;
in Molecular Cancer Research (2008), 5(12), 1331-41
2007
Kapitel 25: Kommunikation zwischen Zellen: Extrazelluläre Signalmoleküle, Rezeptoren und Signaltransduktion; ; ; ; ;
in Löffler, Georg; Petrides, P. E.; Heinrich, Peter C. (Eds.) Biochemie und Pathobiochemie (2007)
Nucleocytoplasmic shuttling of persistently activated STAT3.; ; ; ; ; ; ; ;
in Journal of Cell Science (2007), 120(Pt 18), 3249-61
Sustained IL-6/STAT-3 signaling in cholangiocarcinoma cells due to SOCS-3 epigenetic silencing.; ; ; ; ; ;
in Gastroenterology (2007), 132(1), 384-96
2006
Determinants governing the potency of STAT3 activation via the individual STAT3-recruiting motifs of gp130.; ; ; ; ; ; ; ;
in Cellular Signalling (2006), 18(1), 40-9
2005
Multiple reasons for an inefficient STAT1 response upon IL-6-type cytokine stimulation; ; ; ;
in Cellular Signalling (2005), 17(12), 1542-50
Bow to your partner for signaling.; ; ;
in Nature Structural & Molecular Biology (2005), 12(6), 476-8
The Jak1 SH2 domain does not fulfill a classical SH2 function in Jak/STAT signaling but plays a structural role for receptor interaction and up-regulation of receptor surface expression; ; ; ; ; ; ; ; ;
in Journal of Biological Chemistry (2005), 280(27), 25760-8
Mechanisms of SOCS3 phosphorylation upon interleukin-6 stimulation. Contributions of Src- and receptor-tyrosine kinases.; ; ; ; ; ; ; ;
in Journal of Biological Chemistry (2005), 280(36), 31478-88
2004
Janus kinase (Jak) subcellular localization revisited: the exclusive membrane localization of endogenous Janus kinase 1 by cytokine receptor interaction uncovers the Jak.receptor complex to be equivalent to a receptor tyrosine kinase; ; ; ; ; ; ; ;
in Journal of Biological Chemistry (2004), 279(34), 35486-93
The role of the inhibitors of interleukin-6 signal transduction SHP2 and SOCS3 for desensitization of interleukin-6 signalling; ; ; ; ; ; ; ; ; ; ; ;
in Biochemical Journal (2004), 378(Pt 2), 449-60
STAT3 is enriched in nuclear bodies.; ; ; ; ; ; ; ;
in Journal of Cell Science (2004), 117(Pt 2), 339-49
The chemoattractants, IL-8 and formyl-methionyl-leucyl-phenylalanine, regulate granulocyte colony-stimulating factor signaling by inducing suppressor of cytokine signaling-1 expression.; ; ; ; ; ;
in Journal of immunology (2004), 173(5), 3243-9
2003
A fusion protein of the gp130 and interleukin-6Ralpha ligand-binding domains acts as a potent interleukin-6 inhibitor.; ; ; ; ;
in Journal of Biological Chemistry (2003), 278(19), 16968-72
Tyrosine phosphorylation disrupts elongin interaction and accelerates SOCS3 degradation.; ; ; ; ; ; ;
in Journal of Biological Chemistry (2003), 278(34), 31972-9
Principles of interleukin (IL)-6-type cytokine signalling and its regulation; ; ; ; ;
in Biochemical Journal (2003), 374(Pt 1), 1-20
Fusionierte lösliche Rezeptoren als hochaktive Zytokin-Inhibitoren.; ;
in Biospektrum (2003), Sonderausgabe(9. Jahrgang), 480-483
Activation of STAT3 by IL-6 and IL-10 in primary human macrophages is differentially modulated by suppressor of cytokine signaling 3.; ; ; ; ; ; ;
in Journal of immunology (2003), 170(6), 3263-72
2002
A new high affinity binding site for suppressor of cytokine signaling-3 on the erythropoietin receptor.; ; ; ;
in European Journal of Biochemistry (2002), 269(10), 2516-26
Suppressor of cytokine signaling-3 is recruited to the activated granulocyte-colony stimulating factor receptor and modulates its signal transduction.; ; ; ; ;
in Journal of immunology (2002), 169(3), 1219-27
2000
Cytoplasmic STAT proteins associate prior to activation; ; ; ; ;
in Biochemical Journal (2000), 345 Pt 3
SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130.; ; ; ;
in Journal of Biological Chemistry (2000), 275(17), 12848-56
1999
Characterization and binding specificity of the monomeric STAT3-SH2 domain.; ; ; ; ; ; ;
in Journal of Biological Chemistry (1999), 274(3), 1342-8
