Prof. Dr Ludwig Neyses
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| Fakultät oder Zentrum | |||||||||
| Postadresse |
Université du Luxembourg 2, Avenue de l'Université L-4365 Esch-sur-Alzette |
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| Telefon | (+352) 46 66 44 6206 | ||||||||
| Gesprochene Sprachen | English, French, German, Spanish | ||||||||
| Forschungsaufenthalte in | France, Luxembourg, United Kingdom, Switzerland, USA | ||||||||
Present Position
Professor at the Life Sciences Research Unit, University of Luxembourg
CV overview
Date of Birth: August 24, 1954
Nationality: German
- 2001-03/2013: Chair of Medicine/Cardiology, University of Manchester, UK
Head of the ‘European Studies Programme’, among other senior management roles - 1994-07/2001: Associate Professor of Medicine, University Hospital of Wuerzburg, Germany (Internal Medicine, subspecialty: cardiology). Attending physician (‘Oberarzt’ and ‘apl. Professor’) for both cardiological and general medical patients and interventional activities in the catheterisation laboratory, scientific work.
- 1991: Assistant Professor of Medicine
- 1989 and 1993: Speciality accreditation in Internal Medicine and Cardiology, respectively
- 1982-1990: Training in Internal Medicine and Cardiology at the University Hospitals of Zurich (Profs. Siegenthaler and W. Vetter) and Bonn (Profs. Luederitz and H. Vetter) and training in special interventional techniques at Beaumont Hospital, Royal Oak, Michigan, USA (Drs. William O’ Neill and Cindy Grines).
- 1980-81: Military Service, German Air Force medical corps
- 1972-79: Medical School training in Mainz, Germany (5 years), Montpellier, France (4th year), and Westminster Medical School, London (final year). German and US qualifying final exam (VQE, Visa qualifying exam for US)
Scientific training with:
- M.P. Dierich, Institute of Immunology, Mainz, Germany (MD thesis on complement receptors);
- W. Siegenthaler and W. Vetter, Dep. of Medicine, University Hospital, Zurich, Switzerland (molecular mechanisms of hypertensive heart disease and early atherosclerosis);
- E. Carafoli, Institute of Biochemistry, Federal Institute of Technology, Zurich, Switzerland (calcium transport in the heart);
- R.S. Williams, Cardiovascular Division, Dep. of Medicine, Duke University, Durham, NC (molecular biology of heart failure).
Distinguished Visiting Professor
Natl. University of Singapore, from 11/2007 and offer to head ‘Cardiovascular Research Institute’ in Singapore (declined)
200 Papers
with emphasis on the clinical, translational and molecular aspects of heart disease with wider projects in general molecular biology and genetics
Research stays abroad
covering 20 years in the last 30 years
Languages
- German (mother tongue)
- French and English at near-native level
- Spanish (advanced)
- Italian (beginner)
Last updated on: Freitag, den 26. Oktober 2018
Membership of over 20 Professional Bodies (selection)
- Elected Fellow, Society of Biology, UK
- Scientific Council of the American Heart Association
- Elected Fellow, Society of Cardiac Angiography and Interventions, USA, since 1998
- British Biochemical Society
- German Cardiac Society and German Society of Internal Medicine
- British Cardiovascular Society
- Working Group on Hypertension and the Heart of the European Society of Cardiology
- Working Group on Cellular Biology of the European Society of Cardiology
Membership of Editorial Boards, Advisory Boards, Distinctions (selection)
- Editorial Board, Circulation, 1998-2003 (the leading cardiovascular journal)
- Editorial Board, Journal of Molecular and Cellular Cardiology (1993–1998 and 2004-2007)
- Scientific Committee ‘Archives of Cardiovascular Medicine’ (since 2007)
- Council member, European Section of the International Society for Heart Research (1998-2004)
- Founding Chair, Working Group on Cardiovascular Molecular Biology, German Society of Cardiology (1993-1995)
- Board Member, Heart Failure Association of the European Society of Cardiology, since 2010
- Editorial Board, World Journal of Hypertension, since 2012
- Editorial Board, International Journal of Cardiology: Metabolic and Endocrine, since 2012
- Elected Fellow, Society of Cardiac Angiography and Interventions, USA, since 1998
- Founding Chair, Working Group on Cardiovascular Molecular Biology, German Society of Cardiology (1993-1995)
- Co-chairman, working group “Clinical Pharmacology” of the German Society of Cardiology (1999-2006)
- Board Member, Heart Failure Association of the European Society of Cardiology (since 05/2010)
Last updated on: 19 Dez 2014
- Chair of the review board for 250 million € programme ‘Integrated Treatment and Research Centres’, German Government (2007-2010)
- Board Member, German University ‘Excellence Initiative’ (1.9 billion €)
- Review Board member, 200 million € ‘German Cardiovascular Research Centre’ (2011)
- Board member, SPUM, ‘Spezielle Massnahme Universitätsmedizin’, Switzerland
- OAQ Review of University of Fribourg, Switzerland, 2014
- Review Medical University, Vienna, for Austrian Accreditation Agency (AQA from 01/2015)
- Regular reviewer for all major European funding agencies including SNF as well as international journals
- Distinguished Visiting Professor, Natl. University of Singapore, from 11/2007 and offer to head ‘Cardiovascular Research Institutes’ in Singapore and Edmonton, Canada (declined)
- Several Senior Management Courses, notably the ‘Senior University Management Course’ of the Oxford Said Business School
Last updated on: 19 Dez 2014
- ‘Special Research Centre (SFB)’, German Research Association (1994-2005, co-organiser) (30 million €);
- International Appointee Grant, MRC, UK, 2002-5 (1 million £; one of 4 grants ever awarded through this scheme);
- Programme Grant, MRC, 2006-9 (900 k£), MRC research grant from 2010 (600 k£);
- MRC programme grant 2011-16 (1.25 million £; about 15% success rate).
Cardiovascular lead for an EU-wide programme (EUMODIC, 12 million €) also involved in the same role in its predecessor programme, EUMORPHIA (9 million €).
Cardiovascular Theme lead and Co-Director, Manchester Biomedical Research Centre (40 million £, 2008-11); 10 projects grants, industrial collaborations. etc. between 2009 and 2013.
Last updated on: 19 Dez 2014
2017
Selective inhibition of plasma membrane calcium ATPase 4 improves angiogenesis and vascular reperfusion; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Journal of Molecular and Cellular Cardiology (2017), (109), 38-47
A physician who has crossed many frontiers and has changed direction a number of times ;
in European Heart Journal (2017), 38(37), 27992800
The Plasma Membrane Calcium ATPases and Their Role as Major New Players in Human Disease.; ; ; ;
in Physiological reviews (2017), 97(3), 1089-1125
2016
Risk Related to Pre-Diabetes Mellitus and Diabetes Mellitus in Heart Failure With Reduced Ejection Fraction: Insights From Prospective Comparison of ARNI With ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure Trial.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Circulation. Heart failure (2016), 9(1),
Plasma membrane calcium ATPases (PMCAs) as potential targets for the treatment of essential hypertension.; ; ;
in Pharmacology & therapeutics (2016), 159
The Plasma Membrane Calcium ATPase 4 Signaling in Cardiac Fibroblasts Mediates Cardiomyocyte Hypertrophy; ; ; ; ; ; ; ; ; ;
in Nature Communications (2016)
Effect of renal artery revascularization upon cardiac structure and function in atherosclerotic renal artery stenosis: cardiac magnetic resonance sub-study of the ASTRAL trial.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2016)
2015
Angiotensin receptor neprilysin inhibition compared with enalapril on the risk of clinical progression in surviving patients with heart failure.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Circulation (2015), 131(1), 54-61
Deletion of the intestinal plasma membrane calcium pump, isoform 1, Atp2b1, in mice is associated with decreased bone mineral density and impaired responsiveness to 1, 25-dihydroxyvitamin D3.; ; ; ; ; ; ;
in Biochemical and biophysical research communications (2015), 467(1), 152-6
2014
Plasma membrane calcium ATPase isoform 4 inhibits vascular endothelial growth factor-mediated angiogenesis through interaction with calcineurin.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Arteriosclerosis, thrombosis, and vascular biology (2014), 34(10), 2310-20
Outcomes in patients with acute and stable coronary syndromes; insights from the prospective NOBORI-2 study; ; ; ; ; ; ; ; ;
in PLoS ONE (2014), 9(2),
Minimising radial injury: Prevention is better than cure; ; ; ; ; ;
in EuroIntervention (2014), 10(7), 824-832
Arterial access site utilization in cardiogenic shock in the United Kingdom: is radial access feasible?; ; ; ; ; ; ; ; ;
in American heart journal (2014), 167(6), 900-81
Angiotensin-neprilysin inhibition versus enalapril in heart failure.; ; ; ; ; ; ; ; ; ; ;
in The New England journal of medicine (2014), 371(11), 993-1004
The tumour suppressor Ras-association domain family protein 1A (RASSF1A) regulates TNF-alpha signalling in cardiomyocytes.; ; ; ; ; ; ; ; ;
in Cardiovascular research (2014), 103(1), 47-59
ESC guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD - summary.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Diabetes & vascular disease research (2014), 11(3), 133-73
The mammalian Ste20-like kinase 2 (Mst2) modulates stress-induced cardiac hypertrophy.; ; ; ; ; ; ; ; ; ; ;
in The Journal of biological chemistry (2014), 289(35), 24275-88
2013
Pacing-induced cardiomyopathy: pathophysiological insights through matrix metalloproteinases.; ; ; ; ;
in Heart failure reviews (2013)
Serum sphingolipids level as a novel potential marker for early detection of human myocardial ischaemic injury.; ; ; ; ; ; ; ; ; ; ;
in Frontiers in physiology (2013), 4
Activation of sphingosine-1-phosphate signalling as a potential underlying mechanism of the pleiotropic effects of statin therapy.; ; ; ; ;
in Critical reviews in clinical laboratory sciences (2013), 50(3), 79-89
Biomarker-guided therapies in heart failure: a forum for unified strategies.; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Journal of cardiac failure (2013), 19(8), 592-9
Incretins as a novel therapeutic strategy in patients with diabetes and heart failure.; ; ; ;
in Heart failure reviews (2013), 18(2), 141-8
Atrial fibrillation in heart failure: The sword of Damocles revisited.; ; ;
in World Journal of Cardiology (2013), 5(7), 215-27
A novel immunomodulator, FTY-720 reverses existing cardiac hypertrophy and fibrosis from pressure overload by targeting NFAT (nuclear factor of activated T-cells) signaling and periostin.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Circulation. Heart failure (2013), 6(4), 833-44
Influence of arterial access site selection on outcomes in primary percutaneous coronary intervention: are the results of randomized trials achievable in clinical practice?; ; ; ; ; ; ;
in JACC. Cardiovascular interventions (2013), 6(7), 698-706
Development and characterization of a novel fluorescent indicator protein PMCA4-GCaMP2 in cardiomyocytes.; ; ; ; ; ;
in Journal of molecular and cellular cardiology (2013), 63
Optimisation and validation of a high throughput screening compatible assay to identify inhibitors of the plasma membrane calcium ATPase pump--a novel therapeutic target for contraception and malaria.; ; ; ; ; ; ;
in Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques (2013), 16(2), 217-30
ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD: the Task Force on diabetes, pre-diabetes, and cardiovascular diseases of the European Society of Cardiology (ESC) and developed in collaboration with the European Association for the Study of Diabetes (EASD).; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in European heart journal (2013), 34(39), 3035-87
2012
Disruption of the interaction between PMCA2 and calcineurin triggers apoptosis and enhances paclitaxel-induced cytotoxicity in breast cancer cells.; ; ; ; ; ; ; ; ; ; ;
in Carcinogenesis (2012), 33(12), 2362-8
Role of advanced glycation end products in cardiovascular disease.; ; ;
in World journal of cardiology (2012), 4(4), 90-102
Atrial fibrillation in heart failure: an innocent bystander?; ;
in Current cardiology reviews (2012), 8(4), 273-80
Use of the Sideguard (Cappella) stent in bifurcation lesions: a real-world experience.; ; ; ; ; ; ; ; ; ;
in EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology (2012), 7(10), 1170-80
Influence of access site selection on PCI-related adverse events in patients with STEMI: meta-analysis of randomised controlled trials.; ; ; ; ; ; ;
in Heart (British Cardiac Society) (2012), 98(4), 303-11
Rivaroxaban in patients with a recent acute coronary syndrome.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in The New England journal of medicine (2012), 366(1), 9-19
Cardiac metabolism; from bench to bedside: Diabetic cardiomyopathy, a disease of cardiac metabolism?in Schilling, Joel D.; Mann, Douglas L. (Eds.) Diabetic cardiomyopathy: bench to bedside. (2012)
The German Centre for Cardiovascular Research.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in European heart journal (2012), 33(9), 1033-361036
What strategies are effective for exercise adherence in heart failure? A systematic review of controlled studies.; ; ; ; ; ;
in Heart failure reviews (2012), 17(1), 107-15
2011
Drug eluting stents for the treatment of bare metal in-stent restenosis: long-term outcomes in real world practice.; ; ; ; ; ;
in EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology (2011), 6(6), 748-53
Automated workflows for accurate mass-based putative metabolite identification in LC/MS-derived metabolomic datasets.; ; ; ; ; ; ; ;
in Bioinformatics (2011), 27(8), 1108-12
Calcium signaling dysfunction in heart disease.; ; ;
in BioFactors (Oxford, England) (2011), 37(3), 175-81
Ca2+ signalling in cardiovascular disease: the role of the plasma membrane calcium pumps.; ; ;
in Science China Life Sciences (2011), 54(8), 691-8
The effects of the cardiac myosin activator, omecamtiv mecarbil, on cardiac function in systolic heart failure: a double-blind, placebo-controlled, crossover, dose-ranging phase 2 trial.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Lancet (2011), 378(9792), 676-83
Integration of metabolomics in heart disease and diabetes research: current achievements and future outlook.; ; ;
in Bioanalysis (2011), 3(19), 2205-22
ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: The Task Force for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC).; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in European heart journal (2011), 32(23), 2999-3054
Deprivation of MKK7 in cardiomyocytes provokes heart failure in mice when exposed to pressure overload.; ; ; ; ; ; ; ; ;
in Journal of molecular and cellular cardiology (2011), 50(4), 702-11
Pak1 as a novel therapeutic target for antihypertrophic treatment in the heart.; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Circulation (2011), 124(24), 2702-15
A comparison of drug-eluting stents versus bare metal stents in saphenous vein graft PCI outcomes: a meta-analysis.; ; ; ; ; ; ; ; ;
in Journal of interventional cardiology (2011), 24(2), 172-80
The role of metabolites and metabolomics in clinically applicable biomarkers of disease.; ; ;
in Archives of toxicology (2011), 85(1), 5-17
Plasma membrane calcium pump (PMCA4)-neuronal nitric-oxide synthase complex regulates cardiac contractility through modulation of a compartmentalized cyclic nucleotide microdomain.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in The Journal of biological chemistry (2011), 286(48), 41520-9
Late outcomes of drug eluting and bare metal stents in saphenous vein graft percutaneous coronary intervention.; ; ; ; ; ; ; ; ;
in EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology (2011), 6(8), 985-91
Local signals with global impacts and clinical implications: lessons from the plasma membrane calcium pump (PMCA4).; ; ;
in Biochimica et biophysica acta (2011), 1813(5), 974-8
What influences physical activity in people with heart failure?: a qualitative study.; ; ; ; ; ; ;
in International journal of nursing studies (2011), 48(10), 1234-43
What can we learn from patients with heart failure about exercise adherence? A systematic review of qualitative papers.; ; ; ; ; ; ;
in Health psychology : official journal of the Division of Health Psychology, American Psychological Association (2011), 30(4), 401-10
Mitogen-activated protein kinase kinase 4 deficiency in cardiomyocytes causes connexin 43 reduction and couples hypertrophic signals to ventricular arrhythmogenesis.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in The Journal of biological chemistry (2011), 286(20), 17821-30
2010
What are the thromboembolic risks of heart failure combined with chronic or paroxysmal AF?; ; ;
in Journal of cardiac failure (2010), 16(4), 340-7
Evaluation of plasma membrane calcium/calmodulin-dependent ATPase isoform 4 as a potential target for fertility control.;
in Handbook of experimental pharmacology (2010), (198), 79-95
The effects of adding torasemide to standard therapy on peak oxygen consumption, natriuretic peptides, and quality of life in patients with compensated left ventricular systolic dysfunction.; ; ; ; ; ; ; ;
in European journal of heart failure (2010), 12(7), 746-52
Plasma membrane calcium ATPase proteins as novel regulators of signal transduction pathways.; ; ; ;
in World Journal of Biological Chemistry (2010), 1(6), 201-8
Endothelial nitric oxide synthase activity is inhibited by the plasma membrane calcium ATPase in human endothelial cells.; ; ; ; ; ; ;
in Cardiovascular research (2010), 87(3), 440-8
The plasma membrane calcium ATPase modulates calcium homeostasis, intracellular signaling events and function in platelets.; ; ; ; ; ; ;
in Journal of thrombosis and haemostasis : JTH (2010), 8(12), 2766-74
Targeted deletion of the extracellular signal-regulated protein kinase 5 attenuates hypertrophic response and promotes pressure overload-induced apoptosis in the heart.; ; ; ; ; ; ; ; ; ;
in Circulation Research (2010), 106(5), 961-70
Impaired glucose tolerance and insulin resistance in heart failure: underrecognized and undertreated?; ; ; ; ; ; ; ;
in Journal of cardiac failure (2010), 16(9), 761-8
Resting Pd/Pa measured with intracoronary pressure wire strongly predicts fractional flow reserve.; ; ; ; ; ; ; ;
in The Journal of invasive cardiology (2010), 22(6), 260-5
A meta-analysis of glucose-insulin-potassium therapy for treatment of acute myocardial infarction.; ;
in Experimental & Clinical Cardiology (2010), 15(2), 20-4
Use of the sheathless guide catheter during routine transradial percutaneous coronary intervention: a feasibility study.; ; ; ; ; ; ; ; ;
in Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions (2010), 75(4), 596-602
Measurement of plasma membrane calcium-calmodulin-dependent ATPase (PMCA) activity.; ; ; ; ;
in Methods in molecular biology (Clifton, N.J.) (2010), 637
2009
Atrial fibrillation is under-recognized in chronic heart failure: insights from a heart failure cohort treated with cardiac resynchronization therapy.; ; ; ; ; ; ;
in Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology (2009), 11(10), 1295-300
Physiological implications of the interaction between the plasma membrane calcium pump and nNOS.; ;
in Pflugers Archiv : European journal of physiology (2009), 457(3), 665-71
The cardiovascular phenotype of a mouse model of acromegaly.; ; ; ; ; ; ;
in Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society (2009), 19(5), 413-9
Estrogen receptor alpha interacts with 17beta-hydroxysteroid dehydrogenase type 10 in mitochondria.; ; ;
in Biochemical and biophysical research communications (2009), 384(4), 450-4
Cardiac-specific deletion of mkk4 reveals its role in pathological hypertrophic remodeling but not in physiological cardiac growth.; ; ; ; ; ; ; ; ; ;
in Circulation Research (2009), 104(7), 905-14
A meta-analysis of the prognostic significance of atrial fibrillation in chronic heart failure.; ; ; ; ;
in European journal of heart failure (2009), 11(7), 676-83
Use of the Heartrail II catheter as a distal stent delivery device; an extended case series.; ; ; ; ; ; ;
in EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology (2009), 5(2), 265-71
Specific role of neuronal nitric-oxide synthase when tethered to the plasma membrane calcium pump in regulating the beta-adrenergic signal in the myocardium.; ; ; ; ; ; ; ; ; ;
in The Journal of biological chemistry (2009), 284(18), 12091-8
Ras-association domain family member 1A (RASSF1A)-where the heart and cancer meet.; ;
in Trends in cardiovascular medicine (2009), 19(8), 262-7
Tumor suppressor Ras-association domain family 1 isoform A is a novel regulator of cardiac hypertrophy.; ; ; ; ; ; ; ; ; ; ; ;
in Circulation (2009), 120(7), 607-16
2008
How common is asymptomatic paroxysmal atrial fibrillation in chronic heart failure?; ; ;
in Scandinavian cardiovascular journal : SCJ (2008), 42(6), 366367
Ligand-dependent activation of ER{beta} lowers blood pressure and attenuates cardiac hypertrophy in ovariectomized spontaneously hypertensive rats.; ; ; ; ; ; ; ; ; ; ;
in Cardiovascular research (2008), 77(4), 774-81
Extensive catheter-induced aortic dissection.; ;
in The Canadian journal of cardiology (2008), 24(2), 9-10
Cardiovascular manifestations associated with influenza virus infection.; ;
in International journal of cardiology (2008), 130(3), 304-9
2007
Both estrogen receptor subtypes, alpha and beta, attenuate cardiovascular remodeling in aldosterone salt-treated rats.; ; ; ; ; ; ; ; ;
in Hypertension (2007), 50(2), 432-8
Conditional neuronal nitric oxide synthase overexpression impairs myocardial contractility.; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Circulation Research (2007), 100(3), 32-44
Plasma membrane calcium ATPase and its relationship to nitric oxide signaling in the heart.; ;
in Annals of the New York Academy of Sciences (2007), 1099
Serum metabolomics reveals many novel metabolic markers of heart failure, including pseudouridine and 2-oxoglutarate; ; ; ; ; ; ; ;
in Metabolomics (2007), 3(4), 413-426
The interaction between endogenous calcineurin and the plasma membrane calcium-dependent ATPase is isoform specific in breast cancer cells.; ; ; ; ;
in FEBS letters (2007), 581(21), 4115-9
Mechanisms of disease: An introduction to clinical sciences;
in Tomlinson, H; Heagerty, AM; Weetman, AP; Malik, R (Eds.) Heart Failure (2007)
A change of scene: Ludwig Neyses, MD. Interview by Mark Nicholls.;
in Circulation (2007), 116(3), 13-5
The regulatory function of plasma-membrane Ca(2+)-ATPase (PMCA) in the heart.; ; ;
in Biochemical Society transactions (2007), 35(Pt 5), 927-30
Neuronal nitric oxide synthase signaling in the heart is regulated by the sarcolemmal calcium pump 4b.; ; ; ; ; ; ; ; ; ; ;
in Circulation (2007), 115(4), 483-92
Targeting the sarcolemmal calcium pump: a potential novel strategy for the treatment of cardiovascular disease.; ;
in Cardiovascular & hematological agents in medicinal chemistry (2007), 5(4), 300-4
Promoter polymorphism of the matrix metalloproteinase 3 gene is associated with regurgitation and left ventricular remodelling in mitral valve prolapse patients.; ; ; ;
in European journal of heart failure (2007), 9(10), 1010-7
2006
Functional effects and molecular mechanisms of subtype-selective ERalpha and ERbeta agonists in the cardiovascular system.; ; ; ; ; ;
in Ernst Schering Foundation symposium proceedings (2006), (1), 87-106
Medroxyprogesterone acetate but not drospirenone ablates the protective function of 17 beta-estradiol in aldosterone salt-treated rats.; ; ; ; ; ; ; ; ; ; ;
in Hypertension (2006), 48(5), 994-1001
Absence of alpha 7 integrin in dystrophin-deficient mice causes a myopathy similar to Duchenne muscular dystrophy.; ; ; ; ; ;
in Human molecular genetics (2006), 15(6), 989-98
Current thinking regarding the use of diuretics in heart failure.;
in Heart failure monitor (2006), 5(2), 50-3
Inhibition of nuclear import of calcineurin prevents myocardial hypertrophy.; ; ; ; ; ; ; ;
in Circulation Research (2006), 99(6), 626-35
Aging reduces the efficacy of estrogen substitution to attenuate cardiac hypertrophy in female spontaneously hypertensive rats.; ; ; ; ; ; ; ; ; ; ;
in Hypertension (2006), 48(4), 579-86
[Cardiology in Great Britain].in Deutsche medizinische Wochenschrift (1946) (2006), 131(24), 1409-11
The emergence of plasma membrane calcium pump as a novel therapeutic target for heart disease.; ; ;
in Mini reviews in medicinal chemistry (2006), 6(5), 583-8
The sarcolemmal calcium pump, alpha-1 syntrophin, and neuronal nitric-oxide synthase are parts of a macromolecular protein complex.; ; ; ; ; ; ; ; ; ; ;
in The Journal of biological chemistry (2006), 281(33), 23341-8
Sperm phenotype of mice carrying a gene deletion for the plasma membrane calcium/calmodulin dependent ATPase 4.; ;
in Molecular and cellular endocrinology (2006), 250(1-2), 93-7
2005
Optimization of gene transfer into neonatal rat cardiomyocytes and unmasking of cytomegalovirus promoter silencing.; ; ;
in DNA and cell biology (2005), 24(6), 381-7
The sarcolemmal calcium pump inhibits the calcineurin/nuclear factor of activated T-cell pathway via interaction with the calcineurin A catalytic subunit.; ; ; ; ; ; ; ; ; ; ;
in The Journal of biological chemistry (2005), 280(33), 29479-87
Targeted proteolysis sustains calcineurin activation.; ; ; ; ;
in Circulation (2005), 111(8), 1045-53
Calcium transport in cardiovascular health and disease--the sarcolemmal calcium pump enters the stage.; ;
in Journal of molecular and cellular cardiology (2005), 39(3), 403-6
Diuretic usage in heart failure: a continuing conundrum in 2005.;
in European heart journal (2005), 26(7), 644-9
Pioglitazone reverses down-regulation of cardiac PPARgamma expression in Zucker diabetic fatty rats.; ; ; ; ; ; ; ;
in Biochemical and biophysical research communications (2005), 329(2), 726-32
The estrogen receptor-alpha agonist 16alpha-LE2 inhibits cardiac hypertrophy and improves hemodynamic function in estrogen-deficient spontaneously hypertensive rats.; ; ; ; ; ; ; ; ; ; ;
in Cardiovascular research (2005), 67(4), 604-12
Increased mortality and aggravation of heart failure in estrogen receptor-beta knockout mice after myocardial infarction.; ; ; ; ; ; ; ; ;
in Circulation (2005), 111(12), 1492-8
2004
Novel functional interaction between the plasma membrane Ca2+ pump 4b and the proapoptotic tumor suppressor Ras-associated factor 1 (RASSF1).; ; ; ; ; ; ; ; ; ;
in The Journal of biological chemistry (2004), 279(30), 31318-28
Plasma membrane Ca2+ ATPase 4 is required for sperm motility and male fertility.; ; ; ; ; ; ; ; ; ;
in The Journal of biological chemistry (2004), 279(27), 28220-6
2003
Rational promoter selection for gene transfer into cardiac cells.; ; ; ; ;
in Journal of molecular and cellular cardiology (2003), 35(7), 823-31
The molecular basis of myocardial hypertrophy and heart failure.;
in Trends in molecular medicine (2003), 9(7), 313-21
AT2 receptor activation regulates myocardial eNOS expression via the calcineurin-NF-AT pathway.; ; ; ; ; ;
in FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2003), 17(2), 283-5
Regulation of vascular tone in animals overexpressing the sarcolemmal calcium pump.; ; ; ; ; ;
in The Journal of biological chemistry (2003), 278(42), 41246-52
Interaction of the plasma membrane Ca2+ pump 4b/CI with the Ca2+/calmodulin-dependent membrane-associated kinase CASK.; ; ; ;
in The Journal of biological chemistry (2003), 278(11), 9778-83
Improvement of endothelial dysfunction by selective estrogen receptor-alpha stimulation in ovariectomized SHR.; ; ; ; ; ; ; ;
in Hypertension (2003), 42(5), 991-6
2002
Effect of additional temporary glycoprotein IIb/IIIa receptor inhibition on troponin release in elective percutaneous coronary interventions after pretreatment with aspirin and clopidogrel (TOPSTAR trial).; ; ; ; ; ; ; ; ; ; ; ; ;
in Journal of the American College of Cardiology (2002), 40(4), 662-8
Oestrogen action on the myocardium in vivo: specific and permissive for angiotensin-converting enzyme inhibition.; ; ; ;
in Journal of hypertension (2002), 20(5), 1001-6
A molecular mechanism improving the contractile state in human myocardial hypertrophy.; ; ; ;
in Experimental & Clinical Cardiology (2002), 7(2-3), 151-7
2001
Mechanisms of estrogen receptor action in the myocardium. Rapid gene activation via the ERK1/2 pathway and serum response elements.; ; ; ; ;
in The Journal of biological chemistry (2001), 276(30), 27873-80
Estrogen effects in the myocardium: inhibition of NF-kappaB DNA binding by estrogen receptor-alpha and -beta.; ; ; ;
in Biochemical and biophysical research communications (2001), 286(5), 1153-7
Overexpression of sarcolemmal calcium pump attenuates induction of cardiac gene expression in response to ET-1.; ; ; ; ;
in American journal of physiology. Regulatory, integrative and comparative physiology (2001), 281(3), 699-705
The plasmamembrane calmodulin-dependent calcium pump: a major regulator of nitric oxide synthase I.; ; ; ;
in The Journal of cell biology (2001), 155(2), 201-5
2000
17beta-estradiol prevents programmed cell death in cardiac myocytes.; ; ; ; ; ;
in Biochemical and biophysical research communications (2000), 268(1), 192-200
1999
Combined SSCP and heteroduplex analysis of the human plasma membrane Ca(2+)-ATPase isoform 1 in patients with essential hypertension.; ;
in Biochemical and biophysical research communications (1999), 261(2), 515-20
Induction of Egr-1 mRNA and protein by endothelin 1, angiotensin II and norepinephrine in neonatal cardiac myocytes.; ; ;
in Molecular and cellular biochemistry (1999), 195(1-2), 11-7
1998
[Compression therapy of a ruptured spurious aneurysm].; ; ; ;
in RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin (1998), 168(3), 291-3
Angiotensin converting enzyme inhibition modulates cardiac fibroblast growth.; ; ; ; ; ;
in Journal of hypertension (1998), 16(3), 377-84
Overexpression of the sarcolemmal calcium pump in the myocardium of transgenic rats.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Circulation Research (1998), 83(9), 877-88
1997
Investigation of the Met-267 Arg exchange in isoform 1 of the human plasma membrane calcium pump in patients with essential hypertension by the amplification-created restriction site technique.; ; ;
in Journal of molecular medicine (Berlin, Germany) (1997), 75(1), 62-6
Cardiac myocytes and fibroblasts contain functional estrogen receptors.; ; ; ; ; ;
in FEBS letters (1997), 416(1), 107-12
Effects of moexiprilat on oestrogen-stimulated cardiac fibroblast growth.; ; ; ; ; ;
in British journal of pharmacology (1997), 121(7), 1350-4
Effects of estrogen on skeletal myoblast growth.; ; ; ; ;
in Biochemical and biophysical research communications (1997), 232(2), 373-8
Sex specific mechanisms of cardiovascular disease;
in Stimpel, M; Zanchetti, A (Eds.) Hypertension after menopause (1997)
Modulation of cardiac hypertrophy by estrogens.; ; ; ;
in Zanchetti, Alberto; Devereux, Richard B.; Hansson, Lennart; Gorini, Sergio (Eds.) Hypertension and the Heart (1997)
1996
[Beta blockers in chronic heart failure. Clinical position on the topic].; ; ; ; ; ;
in Der Internist (1996), 37(12), 1274-81279
Expression of the plasma membrane Ca2+-ATPase in myogenic cells.; ; ; ; ; ; ; ;
in The Journal of biological chemistry (1996), 271(48), 30816-22
Molekulare Mekchanismen der Myokardhypertrophiein Ludwig, M; Winter, U (Eds.) Arterosklerotische Gefaessserkrankungen (1996)
Use of antisense oligonucleotides for selective inhibition of gene expression in cardiomyocytes; ; ; ; ; ; ;
in Grote, J; Stick, C (Eds.) Tissue response to hypoxia and ischemia (1996)
Molecular Biology of oncogenes and cardiovascular hypertrophy; ;
in Lindpaintner, K; Ganten, D (Eds.) Molecular Reviews in Cardiovascular Medicine (1996)
1995
Hormonal induction of an immediate-early gene response in myogenic cell lines--a paradigm for heart growth.; ; ; ; ;
in European heart journal (1995), 16 Suppl C
Calcium transport systems in pressure overload cardiomyopathyin Timio, M; Wizemann, V; Venanzi, S (Eds.) Cardionephrology (1995)
The biological cascade leading to cardiac hypertrophy.;
in European heart journal (1995), 16 Suppl N
[Molecular adaptation of the heart to hypertension].;
in Zeitschrift fur Kardiologie (1995), 84 Suppl 4
1994
Effects of nisoldipine on endothelin-1- and angiotensin II-induced immediate/early gene expression and protein synthesis in adult rat ventricular cardiomyocytes.; ; ;
in Journal of cardiovascular pharmacology (1994), 24(1), 13-6
Differentiation-specific isoform mRNA expression of the calmodulin-dependent plasma membrane Ca(2+)-ATPase.; ; ; ; ; ;
in FASEB journal : official publication of the Federation of American Societies for Experimental Biology (1994), 8(6), 428-35
Mitogenic signals control translation of the early growth response gene-1 in myogenic cells.; ; ; ; ;
in Biochemical and biophysical research communications (1994), 202(3), 1337-46
1993
Gap junction protein connexin40 is preferentially expressed in vascular endothelium and conductive bundles of rat myocardium and is increased under hypertensive conditions.; ; ; ; ;
in Circulation Research (1993), 73(6), 1138-49
Immediate-early gene induction by repetitive mechanical but not electrical activity in adult rat cardiomyocytes.; ; ; ; ;
in FEBS letters (1993), 335(1), 37-40
Induction of immediate-early genes by angiotensin II and endothelin-1 in adult rat cardiomyocytes.; ; ; ; ; ; ; ;
in Journal of hypertension (1993), 11(9), 927-34
Hyperosmotic stress induces immediate-early gene expression in ventricular adult cardiomyocytes.; ; ; ;
in Biochemical and biophysical research communications (1993), 194(2), 642-6
1992
[Potassium restriction and essential hypertension].in Deutsche medizinische Wochenschrift (1946) (1992), 117(35), 1341
Die Bedeutung des "early growth response gene-1" bei der Induktion der Hypertensiven Myokardhypertrophie; ; ; ; ;
in Regensburger Universitaetskolloquium: Fortschritte in der medizinischen Forschung - Hypertonie - molekulare Mechanismen/funktionelle Adaptation (1992)
Molecular biology of oncogenes and cardiovascular hypertrophy.;
in Journal of hypertension (1992), 10(12), 1447-52
Angiotensin II induces formation of the early growth response gene-1 protein in rat vascular smooth muscle cells.; ; ; ; ; ;
in FEBS letters (1992), 313(2), 109-12
Sequence analysis of polymerase chain reaction amplified t(14;18) chromosomal breakpoints in formalin fixed, paraffin wax embedded follicular lymphoma.; ; ; ; ; ; ; ; ;
in Journal of clinical pathology (1992), 45(3), 210-2
1991
Kalium-Restriktion und essentielle Hypertoniein Deutsche Medizinische Wochenschrift (1946) (1991), (116), 2417-2248
Isolierte Kardiomyozyten - ein Modell zur Aufklaerung der Pathophysiologie der hypertensiven Herzkrankheit - physiologische und erste molekularbiologische Ergebnisse; ; ; ;
in Ganten, D (Ed.) Herz-Kreislaufregulation, Organprotektion und Organschaden (1991)
Inhibition of endothelin-1 induced myocardial protein synthesis by an antisense oligonucleotide against the early growth response gene-1.; ;
in Biochemical and biophysical research communications (1991), 181(1), 22-7
1990
Isolated myocardial cells: a new tool for the investigation of hypertensive heart disease.;
in Journal of hypertension. Supplement : official journal of the International Society of Hypertension (1990), 8(4), 99-102
[Hypertensive heart disease. Pathophysiological foundation, diagnosis and therapy].;
in Deutsche medizinische Wochenschrift (1946) (1990), 115(39), 1480-6
[Disturbed endothelium-dependent blood vessel relaxation in essential hypertension].;
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Hypertensive Herzkrankheit - pathophysiologische Grundlaten, Diagnostik und Therapie;
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1989
[Increased atrial natriuretic peptide in essential hypertension--relation to right atrial pressure behavior].; ; ; ;
in Klinische Wochenschrift (1989), 67(15), 756-61
Impaired relaxation of the hypertrophied myocardium is potentiated by angiotensin II.;
in Journal of hypertension. Supplement : official journal of the International Society of Hypertension (1989), 7(6), 104-5
Action of atrial natriuretic peptide and angiotensin II on the myocardium: studies in isolated rat ventricular cardiomyocytes.;
in Biochemical and biophysical research communications (1989), 163(3), 1435-43
1988
[Diagnostic and prognostic value of plasma ANP determination after myocardial infarction].; ; ; ;
in Zeitschrift fur Kardiologie (1988), 77 Suppl 2
Diagnostische und prognostische Bedeutung der Plasma-ANP-Messung nach Myokardinfarkt; ; ; ;
in Plasmabestimmung des atrialen natriuretischen Peptids (1988)
[Elevated levels of atrial natriuretic peptide and plasma catecholamines in arterial hypertension--indications for an interaction].; ; ; ; ;
in Zeitschrift fur Kardiologie (1988), 77(7), 407-12
Oxygenated sterols and intracellular calcium dynamics - comparison with cholesterol and clinical application; ; ;
in Beck, J; Crastes de Paulet, A (Eds.) Biological activities of oxygenated sterols (1988)
[Concentrations of amiodarone and flecainide in plasma and saliva--indications for the active transport of flecainide].; ; ;
in Zeitschrift fur Kardiologie (1988), 77(2), 99-102
1987
Einfluss von oraler Volumenbelastung, Herzfrequenz und Reserpin auf die Sekretion von atrialem natriuretischen Peptid beim Menschen; ; ; ;
in Kreye, V; Bussmann, W (Eds.) Atriales natriurestisches Peptid und das kardiovaskulaere System (1987)
[Resuscitation of a 36-year-old patient with a short PQ time and a history of Hodgkin's disease].; ; ;
in Der Internist (1987), 28(3), 196-9
Inhibition of flecainide absorption by activated charcoal.; ; ;
in The American journal of cardiology (1987), 60(8), 753
[Elevated plasma flecainide concentrations in heart failure].; ; ;
in Deutsche medizinische Wochenschrift (1946) (1987), 112(44), 1698-700
1985
Compliance with salt restriction as a limiting factor in the primary prevention of hypertension.; ; ; ; ; ; ; ; ;
in Journal of hypertension. Supplement : official journal of the International Society of Hypertension (1985), 3(1), 87-90
A simple and effective method to teach patients about high blood pressure and obesity.; ; ; ; ; ; ;
in Journal of hypertension. Supplement : official journal of the International Society of Hypertension (1985), 3(1), 27-30
Trilostane - a new and effective drug for primary aldosteronism; ; ;
in The adrenal gland and hypertension (1985)
Stereospecific modulation of the calcium channel in human erythrocytes by cholesterol and its oxidized derivatives.; ; ; ;
in The Biochemical journal (1985), 227(1), 105-12
Phosphorylation of the Ca2+-pumping ATPase of heart sarcolemma and erythrocyte plasma membrane by the cAMP-dependent protein kinase.; ;
in The Journal of biological chemistry (1985), 260(18), 10283-7
[Mechanism of action of calcium antagonists].;
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The mechanism of action of calcium antagonists [DER WIRKUNGSMECHANISMUS DER KALZIUMANTAGONISTEN];
in Schweizerische Rundschau fur Medizin/Praxis (1985), 74(19), 483-490
High density lipoproteins--modulators of the calcium channel?; ; ; ;
in Journal of hypertension. Supplement : official journal of the International Society of Hypertension (1985), 3(3), 49-51
[Divisible tablets--source of error in therapeutic drug dosages].; ; ; ; ; ;
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1984
[Nifedipine in hypertensive emergencies and severe hypertension].; ; ; ; ;
in Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis (1984), 73(2), 45-9
The cholesterol content of the human erythrocyte influences calcium influx through the channel.; ; ; ;
in Biochemical and biophysical research communications (1984), 124(3), 822-8
Angiotensin II binding to human mononuclear cells: receptor or free fluid endocytosis?; ; ; ; ;
in Clinical science (London, England : 1979) (1984), 66(5), 605-12
Cholesterol and its oxidized derivatives modulate the calcium channel in human red blood cells.; ; ; ; ;
in Journal of hypertension. Supplement : official journal of the International Society of Hypertension (1984), 2(3), 489-92
Human red blood cells--an ideal model system for the action of calcium agonists and antagonists.; ; ; ;
in Journal of hypertension. Supplement : official journal of the International Society of Hypertension (1984), 2(3), 577-80
1983
A slide program on hypertension and obesity: a simple method of patient information.; ; ; ; ; ; ;
in Schweizerische medizinische Wochenschrift (1983), 113(50), 1929-33
Beta-blockade in den achtziger Jahrenin Swiss Medical Weekly : Official Journal of the Swiss Society of Infectious Diseases, the Swiss Society of Internal Medicine, the Swiss Society of Pneumology (1983), (4), 79-84
Altered calcium and sodium metabolism in red blood cells of hypertensive man: assessment by ion-selective electrodes.; ; ; ; ; ; ;
in Journal of hypertension (1983), 1(2), 171-6
1982
[Long-term progress following percutaneous transluminal dilatation of renal artery stenosis].; ; ; ; ; ; ; ;
in VASA. Zeitschrift fur Gefasskrankheiten (1982), 11(4), 362-6
Isolation and characterization of the C3b-binding entity of C3b-receptor from human erythrocytes.; ; ; ; ;
in Immunology letters (1982), 4(1), 1-6
