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Anne Grünewald

Associate professor / Chief scientist 2, FNR ATTRACT Fellow

Fakultät oder Zentrum Luxembourg Centre for Systems Biomedicine
Forschungseinheit LCSB
Postadresse Université du Luxembourg
6, avenue du Swing
L-4367 Belvaux
Büroadresse BioTech II, 1.16
E-Mail
Telefon (+352) 46 66 44 9793
Fax (+352) 46 66 44 39793
Video Ass. Prof. Anne Grünewald
Ass. Prof. Anne Grünewald
 
Ass. Prof. Anne Grünewald on her research on Parkinson's disease especially the role of mitochondria, organells responsable for energy supply in the nerve cells affected by the disease.

Principal Investigator in the Molecular and Functional Neurobiology (Grünewald Lab)

Last updated on: Donnerstag, den 06. April 2017

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2019

Ouzren, N., Delcambre, S., Ghelfi, J., Seibler, P., Farrer, M. J., König, I., Aasly, J. O., Trinh, J., Klein, C., & Grünewald, A. (2019). MtDNA deletions discriminate affected from unaffected LRRK2 mutation carriers. Annals of Neurology, 86(2), 324-326.
Peer reviewed
Grossmann, D., Berenguer, C., Bellet, M. E., Scheibner, D., Bohler, J., Massart, F., Rapaport, D., Skupin, A., Fouquier d'Hérouël, A., Sharma, M., Ghelfi, J., Rakovic, A., Lichtner, P., Antony, P., Glaab, E., May, P., Dimmer, K. S., Fitzgerald, J. C., Grünewald, A., & Krüger, R. (2019, July 15). Mutations in RHOT1 disrupt ER-mitochondria contact sites interfering with calcium homeostasis and mitochondrial dynamics in Parkinson's disease. Antioxidants & redox signaling.
Peer reviewed
Grünewald, A., Kumar, K. R., & Sue, C. M. (2019). New insights into the complex role of mitochondria in Parkinson's disease. Progress in Neurobiology, 177, 73-93.
Peer reviewed

2018

Trinh, J.* , Zeldenrust, F. M. J.* , Huang, J.* , Kasten, M.* , Schaake, S., Petkovic, S., Madoev, H., Grünewald, A., Almuammar, S., König, I. R., Lill, C. M., Lohmann, K., Klein, C., & Marras, C. (2018). Genotype-phenotype relations for the Parkinson’s disease genes SNCA, LRRK2, VPS35: MDSGene Review. Movement Disorders, 33(12), 1857-1870.
Peer reviewed
* These authors have contributed equally to this work.
Bolognin, S., Fossépré, M., Qing, X., Jarazo, J., Ščančar, J., Lucumi Moreno, E., Nickels, S., Wasner, K., Ouzren, N., Walter, J., Grünewald, A., Glaab, E., Salamanca, L., Fleming, R. M. T., Antony, P., & Schwamborn, J. C. (2018, November). 3D Cultures of Parkinson's Disease‐Specific Dopaminergic Neurons for High Content Phenotyping and Drug Testing. Advanced Science.
Peer reviewed
Grünewald, A. (2018). Mutationen im VSP13D-Gen verursachen eine oftmals frühkindliche spastische Ataxie. DGNeurologie, 1(1), 58-59.
Peer reviewed
Vincent, A. E., Rosa, H. S., Pabis, K., Lawless, C., Chen, C., Grünewald, A., Rygiel, K. A., Rocha, M. C., Reeve, A. K., Falkous, G., Perissi, V., White, K., Davy, T., Petrof, B. J., Sayer, A. A., Cooper, C., Deehan, D., Taylor, R. W., Turnbull, D. M., & Picard, M. (2018). Subcellular origin of mitochondrial DNA deletions in human skeletal muscle. Annals of Neurology, 84(2), 289-301.
Peer reviewed (verified by ORBilu)

2017

Grütz, K., Weisbach, A., Lohmann, K., Carlisle, F., Blake, D. J., Westenberger, A., Klein, C., & Grünewald, A. (2017). Faithful SGCE imprinting in iPSC-derived cortical neurons: an endogenous cellular model of myoclonus-dystonia. Scientific Reports.
Peer reviewed (verified by ORBilu)
Wagner, J., Vulinovic, F., Grünewald, A., Unger, M., Möller, C., Klein, C., Michel, P., Ries, V., Oertel, W., & Alvarez-Fischer, D. (2017). Acylated and unacylated ghrelin confers neuroprotection to mesencephalic neurons. Neuroscience.
Peer reviewed (verified by ORBilu)
Zanon, A., Kalvakuri, S., Rakovic, A., Foco, L., Guida, A., Schwienbacher, C., Serafin, A., Rudolf, F., Grünewald, A., Stanslowsky, N., Wegner, F., Giorgio, V., Lavdas, A., Bodmer, R., Pramstaller, P., Klein, C., Hicks, A., Pichler, I., & Seibler, P. (2017). SLP-2 interacts with Parkin in mitochondria and prevents mitochondrial dysfunction in Parkin-deficient human iPSC-derived neurons and Drosophila. Human Molecular Genetics.
Peer reviewed (verified by ORBilu)

2016

Grünewald, A., Rygiel, K. A., Hepplewhite, P. D., Morris, C. M., Picard, M., & Turnbull, D. M. (2016). Mitochondrial DNA depletion in respiratory chain-deficient Parkinson disease neurons. Annals of Neurology, 79(3), 366-378.
Peer reviewed (verified by ORBilu)
Grünewald, A., & Klein, C. (2016). Urinary LRRK2 phosphorylation: Penetrating the thicket of Parkinson disease? Neurology.
Peer reviewed (verified by ORBilu)

2015

Deuse, T., Wang, D., Stubbendorff, M., Itagaki, R., Grabosch, A., Greaves, L. C., Alawi, M., Grünewald, A., Hu, X., Hua, X., Velden, J., Reichenspurner, H., Robbins, R. C., Jaenisch, R., Weissman, I. L., & Schrepfer, S. (2015). SCNT-derived ESCs with mismatched mitochondria trigger an immune response in allogeneic hosts. Cell Stem Cell, 16(1), 33-8.
Peer reviewed (verified by ORBilu)
Rocha, M. C.* , Grady, J. P.* , Grünewald, A., Vincent, A., Dobson, P. F., Taylor, R. W., Turnbull, D. M., & Rygiel, K. A. (2015). A novel immunofluorescent assay to investigate oxidative phosphorylation deficiency in mitochondrial myopathy: understanding mechanisms and improving diagnosis. Scientific reports, 5, 15037.
Peer reviewed (verified by ORBilu)
* These authors have contributed equally to this work.

2014

Erogullari, A., Hollstein, R., Seibler, P., Braunholz, D., Koschmidder, E., Depping, R., Eckhold, J., Lohnau, T., Gillessen-Kaesbach, G., Grünewald, A., Rakovic, A., Lohmann, K., & Kaiser, F. J. (2014). THAP1, the gene mutated in DYT6 dystonia, autoregulates its own expression. Biochimica et biophysica acta, 1839(11), 1196-204.
Peer reviewed (verified by ORBilu)
Grünewald, A.* , Arns, B.* , Meier, B., Brockmann, K., Tadic, V., & Klein, C. (2014). Does uncoupling protein 2 expression qualify as marker of disease status in LRRK2-associated Parkinson's disease? Antioxidants & redox signaling, 20(13), 1955-60.
Peer reviewed (verified by ORBilu)
* These authors have contributed equally to this work.
Grünewald, A., Lax, N. Z., Rocha, M. C., Reeve, A. K., Hepplewhite, P. D., Rygiel, K. A., Taylor, R. W., & Turnbull, D. M. (2014). Quantitative quadruple-label immunofluorescence of mitochondrial and cytoplasmic proteins in single neurons from human midbrain tissue. Journal of neuroscience methods, 232, 143-9.
Peer reviewed (verified by ORBilu)
Lohmann, K., Schmidt, A., Schillert, A., Winkler, S., Albanese, A., Baas, F., Bentivoglio, A. R., Borngraber, F., Bruggemann, N., Defazio, G., Del Sorbo, F., Deuschl, G., Edwards, M. J., Gasser, T., Gomez-Garre, P., Graf, J., Groen, J. L., Grünewald, A., Hagenah, J., Hemmelmann, C., Jabusch, H.-C., Kaji, R., Kasten, M., Kawakami, H., Kostic, V. S., Liguori, M., Mir, P., Munchau, A., Ricchiuti, F., Schreiber, S., Siegesmund, K., Svetel, M., Tijssen, M. A. J., Valente, E. M., Westenberger, A., Zeuner, K. E., Zittel, S., Altenmuller, E., Ziegler, A., & Klein, C. (2014). Genome-wide association study in musician's dystonia: a risk variant at the arylsulfatase G locus? Movement disorders : official journal of the Movement Disorder Society, 29(7), 921-7.
Peer reviewed (verified by ORBilu)
Morais, V. A., Haddad, D., Craessaerts, K., De Bock, P.-J., Swerts, J., Vilain, S., Aerts, L., Overbergh, L., Grünewald, A., Seibler, P., Klein, C., Gevaert, K., Verstreken, P., & De Strooper, B. (2014). PINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncoupling. Science (New York, N.Y.), 344(6180), 203-7.
Peer reviewed (verified by ORBilu)

2013

Alvarez-Fischer, D., Noelker, C., Grünewald, A., Vulinovic, F., Guerreiro, S., Fuchs, J., Lu, L., Lombes, A., Hirsch, E. C., Oertel, W. H., Michel, P. P., & Hartmann, A. (2013). Probenecid potentiates MPTP/MPP+ toxicity by interference with cellular energy metabolism. Journal of neurochemistry, 127(6), 782-92.
Peer reviewed (verified by ORBilu)
Alvarez-Fischer, D., Noelker, C., Vulinovic, F., Grünewald, A., Chevarin, C., Klein, C., Oertel, W. H., Hirsch, E. C., Michel, P. P., & Hartmann, A. (2013). Bee venom and its component apamin as neuroprotective agents in a Parkinson disease mouse model. PloS one, 8(4), 61700.
Peer reviewed (verified by ORBilu)
Freimann, K., Zschiedrich, K., Bruggemann, N., Grünewald, A., Pawlack, H., Hagenah, J., Lohmann, K., Klein, C., & Westenberger, A. (2013). Mortalin mutations are not a frequent cause of early-onset Parkinson disease. Neurobiology of aging, 34(11), 2694.e19-20.
Peer reviewed (verified by ORBilu)
Grünewald, A.* , Kasten, M.* , Ziegler, A., & Klein, C. (2013). Next-generation phenotyping using the parkin example: time to catch up with genetics. JAMA neurology, 70(9), 1186-91.
Peer reviewed (verified by ORBilu)
* These authors have contributed equally to this work.
Kasten, M., Grünewald, A., & Klein, C. (2013). Next-generation phenotyping and genomic incidental findings--reply. JAMA neurology, 70(12), 1590-1.
Peer reviewed (verified by ORBilu)
Kumar, K. R., Ramirez, A., Gobel, A., Kresojevic, N., Svetel, M., Lohmann, K., M Sue, C., Rolfs, A., Mazzulli, J. R., Alcalay, R. N., Krainc, D., Klein, C., Kostic, V., & Grünewald, A. (2013). Glucocerebrosidase mutations in a Serbian Parkinson's disease population. European journal of neurology, 20(2), 402-5.
Peer reviewed (verified by ORBilu)
Kumar, K. R., Blair, N. F., Vandebona, H., Liang, C., Ng, K., Sharpe, D. M., Grünewald, A., Golnitz, U., Saviouk, V., Rolfs, A., Klein, C., & Sue, C. M. (2013). Targeted next generation sequencing in SPAST-negative hereditary spastic paraplegia. Journal of neurology, 260(10), 2516-22.
Peer reviewed (verified by ORBilu)
Rakovic, A., Shurkewitsch, K., Seibler, P., Grünewald, A., Zanon, A., Hagenah, J., Krainc, D., & Klein, C. (2013). Phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1)-dependent ubiquitination of endogenous Parkin attenuates mitophagy: study in human primary fibroblasts and induced pluripotent stem cell-derived neurons. The Journal of biological chemistry, 288(4), 2223-37.
Peer reviewed (verified by ORBilu)
Weissbach, A., Kasten, M., Grünewald, A., Bruggemann, N., Trillenberg, P., Klein, C., & Hagenah, J. (2013). Prominent psychiatric comorbidity in the dominantly inherited movement disorder myoclonus-dystonia. Parkinsonism & related disorders, 19(4), 422-5.
Peer reviewed (verified by ORBilu)

2012

Grünewald, A.* , Arns, B.* , Seibler, P., Rakovic, A., Munchau, A., Ramirez, A., Sue, C. M., & Klein, C. (2012). ATP13A2 mutations impair mitochondrial function in fibroblasts from patients with Kufor-Rakeb syndrome. Neurobiology of aging, 33(8), 1843.e1-7.
Peer reviewed (verified by ORBilu)
* These authors have contributed equally to this work.
Schmidt, A., Kumar, K. R., Redyk, K., Grünewald, A., Leben, M., Munchau, A., Sue, C. M., Hagenah, J., Hartmann, H., Lohmann, K., Christen, H.-J., & Klein, C. (2012). Two faces of the same coin: benign familial infantile seizures and paroxysmal kinesigenic dyskinesia caused by PRRT2 mutations. Archives of neurology, 69(5), 668-70.
Peer reviewed (verified by ORBilu)
Wortmann, S. B., Vaz, F. M., Gardeitchik, T., Vissers, L. E. L. M., Renkema, G. H., Schuurs-Hoeijmakers, J. H. M., Kulik, W., Lammens, M., Christin, C., Kluijtmans, L. A. J., Rodenburg, R. J., Nijtmans, L. G. J., Grünewald, A., Klein, C., Gerhold, J. M., Kozicz, T., van Hasselt, P. M., Harakalova, M., Kloosterman, W., Baric, I., Pronicka, E., Ucar, S. K., Naess, K., Singhal, K. K., Krumina, Z., Gilissen, C., van Bokhoven, H., Veltman, J. A., Smeitink, J. A. M., Lefeber, D. J., Spelbrink, J. N., Wevers, R. A., Morava, E., & de Brouwer, A. P. M. (2012). Mutations in the phospholipid remodeling gene SERAC1 impair mitochondrial function and intracellular cholesterol trafficking and cause dystonia and deafness. Nature genetics, 44(7), 797-802.
Peer reviewed (verified by ORBilu)

2011

Abramov, A. Y., Gegg, M., Grünewald, A., Wood, N. W., Klein, C., & Schapira, A. H. V. (2011). Bioenergetic consequences of PINK1 mutations in Parkinson disease. PloS one, 6(10), 25622.
Peer reviewed (verified by ORBilu)
Arif, B., Grünewald, A., Fatima, A., Ramirez, A., Ali, A., Bruggemann, N., Wurfel, J., Rolfs, A., Lohmann, K., Malik, A., Klein, C., & Naz, S. (2011). An unusual neurological syndrome of crawling gait, dystonia, pyramidal signs, and limited speech. Movement disorders : official journal of the Movement Disorder Society, 26(12), 2279-83.
Peer reviewed (verified by ORBilu)
Kumar, K. R., Djarmati-Westenberger, A., & Grünewald, A. (2011). Genetics of Parkinson's disease. Seminars in neurology, 31(5), 433-40.
Peer reviewed (verified by ORBilu)
Rakovic, A.* , Grünewald, A.* , Kottwitz, J., Bruggemann, N., Pramstaller, P. P., Lohmann, K., & Klein, C. (2011). Mutations in PINK1 and Parkin impair ubiquitination of Mitofusins in human fibroblasts. PloS one, 6(3), 16746.
Peer reviewed (verified by ORBilu)
* These authors have contributed equally to this work.
Rakovic, A.* , Grünewald, A.* , Voges, L., Hofmann, S., Orolicki, S., Lohmann, K., & Klein, C. (2011). PINK1-interacting proteins: Proteomic analysis of overexpressed PINK1. Parkinsons Dis, 2011, 153979.
Peer reviewed
* These authors have contributed equally to this work.

2010

Grünewald, A., Voges, L., Rakovic, A., Kasten, M., Vandebona, H., Hemmelmann, C., Lohmann, K., Orolicki, S., Ramirez, A., Schapira, A. H. V., Pramstaller, P. P., Sue, C. M., & Klein, C. (2010). Mutant Parkin impairs mitochondrial function and morphology in human fibroblasts. PloS one, 5(9), 12962.
Peer reviewed (verified by ORBilu)
Rakovic, A., Grünewald, A., Seibler, P., Ramirez, A., Kock, N., Orolicki, S., Lohmann, K., & Klein, C. (2010). Effect of endogenous mutant and wild-type PINK1 on Parkin in fibroblasts from Parkinson disease patients. Human molecular genetics, 19(16), 3124-37.
Peer reviewed (verified by ORBilu)

2009

Grünewald, A., Gegg, M. E., Taanman, J.-W., King, R. H., Kock, N., Klein, C., & Schapira, A. H. V. (2009). Differential effects of PINK1 nonsense and missense mutations on mitochondrial function and morphology. Experimental neurology, 219(1), 266-73.
Peer reviewed (verified by ORBilu)

2008

Brueggemann, N., Odin, P., Gruenewald, A., Tadic, V., Hagenah, J., Seidel, G., Lohmann, K., Klein, C., & Djarmati, A. (2008). Re: Alpha-synuclein gene duplication is present in sporadic Parkinson disease. Neurology, 71(16), 1294; author reply 1294.
Peer reviewed (verified by ORBilu)
Grünewald, A., Djarmati, A., Lohmann-Hedrich, K., Farrell, K., Zeller, J. A., Allert, N., Papengut, F., Petersen, B., Fung, V., Sue, C. M., O'Sullivan, D., Mahant, N., Kupsch, A., Chuang, R. S., Wiegers, K., Pawlack, H., Hagenah, J., Ozelius, L. J., Stephani, U., Schuit, R., Lang, A., Volkmann, J., Munchau, A., & Klein, C. (2008). Myoclonus-dystonia: significance of large SGCE deletions. Human mutation, 29(2), 331-2.
Peer reviewed (verified by ORBilu)
Paus, S., Grünewald, A., Klein, C., Knapp, M., Zimprich, A., Janetzky, B., Moller, J. C., Klockgether, T., & Wullner, U. (2008). The DRD2 TaqIA polymorphism and demand of dopaminergic medication in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society, 23(4), 599-602.
Peer reviewed (verified by ORBilu)

2007

Djarmati, A.* , Guzvic, M.* , Grünewald, A., Lang, A. E., Pramstaller, P. P., Simon, D. K., Kaindl, A. M., Vieregge, P., Nygren, A. O. H., Beetz, C., Hedrich, K., & Klein, C. (2007). Rapid and reliable detection of exon rearrangements in various movement disorders genes by multiplex ligation-dependent probe amplification. Movement disorders : official journal of the Movement Disorder Society, 22(12), 1708-14.
Peer reviewed (verified by ORBilu)
* These authors have contributed equally to this work.
Grünewald, A., Breedveld, G. J., Lohmann-Hedrich, K., Rohe, C. F., Konig, I. R., Hagenah, J., Vanacore, N., Meco, G., Antonini, A., Goldwurm, S., Lesage, S., Durr, A., Binkofski, F., Siebner, H., Munchau, A., Brice, A., Oostra, B. A., Klein, C., & Bonifati, V. (2007). Biological effects of the PINK1 c.1366C>T mutation: implications in Parkinson disease pathogenesis. Neurogenetics, 8(2), 103-9.
Peer reviewed (verified by ORBilu)
Orth, M., Djarmati, A., Baumer, T., Winkler, S., Grünewald, A., Lohmann-Hedrich, K., Kabakci, K., Hagenah, J., Klein, C., & Munchau, A. (2007). Autosomal dominant myoclonus-dystonia and Tourette syndrome in a family without linkage to the SGCE gene. Movement disorders : official journal of the Movement Disorder Society, 22(14), 2090-6.
Peer reviewed (verified by ORBilu)

2006

Hedrich, K., Hagenah, J., Djarmati, A., Hiller, A., Lohnau, T., Lasek, K., Grünewald, A., Hilker, R., Steinlechner, S., Boston, H., Kock, N., Schneider-Gold, C., Kress, W., Siebner, H., Binkofski, F., Lencer, R., Munchau, A., & Klein, C. (2006). Clinical spectrum of homozygous and heterozygous PINK1 mutations in a large German family with Parkinson disease: role of a single hit? Archives of neurology, 63(6), 833-8.
Peer reviewed (verified by ORBilu)
Klein, C., Grünewald, A., & Hedrich, K. (2006). Early-onset parkinsonism associated with PINK1 mutations: frequency, genotypes, and phenotypes. Neurology, 66(7), 1129-30; author reply 1129-30.
Peer reviewed (verified by ORBilu)