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Cyrille Thinnes

Postdoctoral researcher / Research associate

Fakultät oder Zentrum Luxembourg Centre for Systems Biomedicine
Forschungseinheit LCSB
Postadresse Université du Luxembourg
6, avenue du Swing
L-4367 Belvaux
Büroadresse BioTech II Ketterthill, 4.06
E-Mail
Telefon (+352) 46 66 44 9400
Fax (+352) 46 66 44 39400

Project manager for the NCER-PD programme

The research programme of the National Centre of Excellence in Research on Parkinson's Disease (NCER-PD) focuses on improving the diagnosis and stratification of Parkinson's disease (PD) by combining detailed clinical and molecular data of patients with sophisticated bioinformatics analyses and computational modelling to develop novel disease biomarker signatures. Due to the collaboration with outstanding international partners and longitudinal cohorts in Oxford, Kassel and Tübingen, the programme aims to generate an unprecedented insight into the early phase of the disease. Moreover, the LCSB collaborates with all relevant players in Luxembourg, such as the Centre Hospitalier de Luxembourg, the Luxembourg Institute of Health, and the Integrated BioBank of Luxembourg, in order to establish a comprehensive national PD cohort. Within this scope, the LCSB will establish an international platform for secure storage and intensive analysis of PD genome data. With its existing IT infrastructure and expertise, the LCSB plays a pivotal role in Big Data management. Together, the multidisciplinarity of the NCER-PD consortium will form the basis to reach its ultimate goal to diagnose PD at an earlier stage, and with a higher specificity than is currently possible.

Last updated on: Dienstag, den 05. April 2016

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2019

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See detailSelective Inhibitors of a Human Prolyl Hydroxylase (OGFOD1) Involved in Ribosomal Decoding.
Thinnes, Cyrille; Lohans, Christopher T.; Abboud, Martine I.; Yeh, Tzu-Lan; Tumber, Anthony; Nowak, Radoslaw P.; Attwood, Martin; Cockman, Matthew E.; Oppermann, Udo; Loenarz, Christoph; Schofield, Christopher J.

in Chemistry (Weinheim an der Bergstrasse, Germany) (2019), 25(8), 2019-2024

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2017

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See detailComplement C1q is hydroxylated by collagen prolyl 4 hydroxylase and is sensitive to off-target inhibition by prolyl hydroxylase domain inhibitors that stabilize hypoxia-inducible factor.
Kiriakidis, Serafim; Hoer, Simon S.; Burrows, Natalie; Biddlecome, Gloria; Khan, Moddasar N.; Thinnes, Cyrille; Schofield, Christopher J.; Rogers, Norma; Botto, Marina; Paleolog, Ewa; Maxwell, Patrick H.

in Kidney international (2017), 92(4), 900-908

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See detailGlucose Metabolism and Oxygen Availability Govern Reactivation of the Latent Human Retrovirus HTLV-1.
Kulkarni, Anurag; Mateus, Manuel; Thinnes, Cyrille; McCullagh, James S.; Schofield, Christopher J.; Taylor, Graham P.; Bangham, Charles R. M.

in Cell chemical biology (2017), 24(11), 1377-13873

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See detailMolecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials.
Yeh, Tzu-Lan; Leissing, Thomas M.; Abboud, Martine I.; Thinnes, Cyrille; Atasoylu, Onur; Holt-Martyn, James P.; Zhang, Dong; Tumber, Anthony; Lippl, Kerstin; Lohans, Christopher T.; Leung, Ivanhoe K. H.; Morcrette, Helen; Clifton, Ian J.; Claridge, Timothy D. W.; Kawamura, Akane; Flashman, Emily; Lu, Xin; Ratcliffe, Peter J.; Chowdhury, Rasheduzzaman; Pugh, Christopher W.; Schofield, Christopher J.

in Chemical science (2017), 8(11), 7651-7668

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2016

See detailTherapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models.
Karuppagounder, Saravanan S.; Alim, Ishraq; Khim, Soah J.; Bourassa, Megan W.; Sleiman, Sama F.; John, Roseleen; Thinnes, Cyrille; Yeh, Tzu-Lan; Demetriades, Marina; Neitemeier, Sandra; Cruz, Dana; Gazaryan, Irina; Killilea, David W.; Morgenstern, Lewis; Xi, Guohua; Keep, Richard F.; Schallert, Timothy; Tappero, Ryan V.; Zhong, Jian; Cho, Sunghee; Maxfield, Frederick R.; Holman, Theodore R.; Culmsee, Carsten; Fong, Guo-Hua; Su, Yijing; Ming, Guo-Li; Song, Hongjun; Cave, John W.; Schofield, Christopher J.; Colbourne, Frederick; Coppola, Giovanni; Ratan, Rajiv R.

in Science translational medicine (2016), 8(328), 32829

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2015

See detailStructure of the ribosomal oxygenase OGFOD1 provides insights into the regio- and stereoselectivity of prolyl hydroxylases.
Horita, Shoichiro; Scotti, John S.; Thinnes, Cyrille; Mottaghi-Taromsari, Yousef S.; Thalhammer, Armin; Ge, Wei; Aik, Weishen; Loenarz, Christoph; Schofield, Christopher J.; McDonough, Michael A.

in Structure (London, England : 1993) (2015), 23(4), 639-52

See detailBetti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxoglutarate oxygenases.
Thinnes, Cyrille; Tumber, A.; Yapp, C.; Scozzafava, G.; Yeh, T.; Chan, M. C.; Tran, T. A.; Hsu, K.; Tarhonskaya, H.; Walport, L. J.; Wilkins, S. E.; Martinez, E. D.; Muller, S.; Pugh, C. W.; Ratcliffe, P. J.; Brennan, P. E.; Kawamura, A.; Schofield, C. J.

in Chemical Communications (2015), 51(84), 15458-61

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2014

See detailStructure-activity relationships and colorimetric properties of specific probes for the putative cancer biomarker human arylamine N-acetyltransferase 1.
Egleton, James E.; Thinnes, Cyrille; Seden, Peter T.; Laurieri, Nicola; Lee, Siu Po; Hadavizadeh, Kate S.; Measures, Angelina R.; Jones, Alan M.; Thompson, Sam; Varney, Amy; Wynne, Graham M.; Ryan, Ali; Sim, Edith; Russell, Angela J.

in Bioorganic & Medicinal Chemistry (2014), 22(11), 3030-54

See detailTargeting histone lysine demethylases - progress, challenges, and the future.
Thinnes, Cyrille; England, Katherine S.; Kawamura, Akane; Chowdhury, Rasheduzzaman; Schofield, Christopher J.; Hopkinson, Richard J.

in Biochimica et biophysica acta (2014), 1839(12), 1416-32

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2013

See detail5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation.
Hopkinson, Richard J.; Tumber, Anthony; Yapp, Clarence; Chowdhury, Rasheduzzaman; Aik, Weishen; Che, Ka Hing; Li, Xuan Shirley; Kristensen, Jan B. L.; King, Oliver N. F.; Chan, Mun Chiang; Yeoh, Kar Kheng; Choi, Hwanho; Walport, Louise J.; Thinnes, Cyrille; Bush, Jacob T.; Lejeune, Clarisse; Rydzik, Anna M.; Rose, Nathan R.; Bagg, Eleanor A.; McDonough, Michael A.; Krojer, Tobias; Yue, Wyatt W.; Ng, Stanley S.; Olsen, Lars; Brennan, Paul E.; Oppermann, Udo; Muller-Knapp, Susanne; Klose, Robert J.; Ratcliffe, Peter J.; Schofield, Christopher J.; Kawamura, Akane

in Chemical Science (2013), 4(8), 3110-3117

See detailA novel color change mechanism for breast cancer biomarker detection: naphthoquinones as specific ligands of human arylamine N-acetyltransferase 1.
Laurieri, Nicola; Egleton, James E.; Varney, Amy; Thinnes, Cyrille; Quevedo, Camilo E.; Seden, Peter T.; Thompson, Sam; Rodrigues-Lima, Fernando; Dairou, Julien; Dupret, Jean-Marie; Russell, Angela J.; Sim, Edith

in PloS one (2013), 8(8), 70600

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