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Prof. Dr. Michael Heneka

Michael Heneka

Director of the "Luxembourg Centre for Systems Biomedicine"

Postadresse Université du Luxembourg
6, avenue du Swing
L-4367 Belvaux
Büroadresse BioTech II, 2.02
E-Mail
Telefon (+352) 46 66 44 6922

Michael Heneka is a board-certified neurologist and clinician-scientist with over 25 years of experience in studying neurodegenerative diseases at experimental, preclinical and clinical levels. He has a long-standing interest in immunology and neuroscience. While the main focus of his work is related to dementia and Alzheimer’s disease, he has also been working on Amyotrophic Lateral Sclerosis and Parkinson’s disease.

At the clinical level, he had established a neurodegenerative outpatient unit at both the University of Münster and the University of Bonn in Germany. From 2016 to 2021, he led the department of Neurodegenerative Disease and Geriatric Psychiatry in Bonn. From January 2022 onwards, he is the Director of the Luxembourg Centre for Systems Biomedicine (LCSB) at the University of Luxembourg and Principal Investigator in the Neuroinflammation group (Heneka Lab)

Last updated on: Mittwoch, den 23. Februar 2022

Education

  • Doctoral thesis, Department of Pharmacology and Toxicology, University of Tübingen (1998)
  • Medical Degree, University of Tübingen, University of London, University of Lausanne (1996)
  • Philosophy Studies, University of Tübingen (1995)

Professional/academic career

University of Bonn, DE

  • Professor for Clinical Neurosciences, Head of the Clinical Neuroscience Unit, Director of the Clinical Treatment and Research Center (KBFZ), Department of Neurology (2008-2021)
  • Director, Department of Neurodegenerative Disease and Geriatric Psychiatry (2016-2021)

University of Massachusetts Medical School, USA (2012-present)

  • Adjunct Prof. of Medicine. Department of Internal Medicine, Division Infectious Diseases and Immunology

University of Münster, DE (2004-2008)

  • Professor for Molecular Neurology, Senior Consultant Neurologist, Department of Neurology

University of Bonn, DE (2004)

  • Senior Consultant Neurologist

Case Western Reserve University, USA (2003)

  • Research Associate Professor at the „Alzheimer Research“, Department of Neurosciences

University of Bonn, DE

  • Consultant/senior clinical fellow, Neurophysiology Unit, Department of Neurology (2003)
    • Venia legendi/Habilitation for Neurology: Inflammatory mechanism in Alzheimer’s disease: characterization and development of therapeutic strategies (2003)
    • Board examination in Neurology (2002)
    • Clinical Fellow, Department of Neurology (1999-2001), Department of Psychiatry (2001-2002)

University of Illinois, USA (1998)

  • Visiting Scholar at the laboratory for „NeuroAnesthesia Research“

University of Tubingen, DE

  • Clinical Fellow, Department of Neurology, 1998
  • Residency, Department of Neurology, 1996-1997

Clinical Expertise

University Hospital Bonn, DE (2016-2021)

  • Director and medical head of the Department of Neurodegenerative Disease and Geriatric Psychiatry

University Hospital Bonn, DE (2008-2016)

  • Head of the section „motoneuron disorders“
  • Chief medical supervision of patients with neurodegenerative disease.
  • Head of the Clinical Center for Treatment and Reseach (KBFZ).
  • Head of the Clinical Neuroscience Unit (CNU)

University of Münster, DE (2004-2008)

  • Prof. of Molecular Neurology, Senior Consultant Neurologist
  • Head of the Memory Clinic of the Dept. of Neurology.
  • Head of the Department of Molecular Neurology.

University of Bonn, DE (2002-2003)

  • Senior Consultant Neurologist for Neurophysiology (Funktionsoberarzt)
  • Senior Consultant Neurologist

University of Tübingen and University of Bonn, DE (1997-2002)

  • Resident, Departments of Neurology



Last updated on: 23 Feb 2022

Scientific participation

  • Board Member Kompetenznetz Neurodegenenerative Demenzen, since 2007
  • Head of the Clinical Research Group 177 (German Research Council), since 2008
  • Editorial Board, Journal of Neurochemistry, 2008-2020
  • Editorial Board, Molecular Neurobiology, since 2012
  • Associate Editor, Neurology, Neuroimmunology and Neuroinflammation, 2015-2020
  • Editorial Board, Alzheimer Research & Therapy, since 2016
  • Editorial Board, ASN Neuro, since 2018
  • Board Member DFG Exzellenzcluster Immunosensation, since 2018
  • Associate Editor, Alzheimer Research & Therapy, since 2019
  • Science Advisory Board, Paris Brain Institute, France, since 2017
  • Science Advisory Board, Dementia Research Institute, UK, since 2018



Last updated on: 23 Feb 2022

  • WO 2005/016339 A1, “Antiinflammatory methods for treatment of Parkinson`s disease”, together with Prof. G.E. Landreth.
  • EP09009085.3a: Inhibitors of the nitration of amyloid beta peptides and their uses in the diagnosis and treatment of Alzheimer's disease, 2009



Last updated on: 23 Feb 2022

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2023

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See detailApoE4 makes microglia trem(2)bling.
Heneka, Michael

in Neuron (2023), 111(2), 142-144

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See detailReactive microglia are the major source of tumor necrosis factor alpha and contribute to astrocyte dysfunction and acute seizures in experimental temporal lobe epilepsy.
Henning, Lukas; Antony, Henrike; Breuer, Annika; Müller, Julia; Seifert, Gerald; Audinat, Etienne; Singh, Parmveer; Brosseron, Frederic; Heneka, Michael; Steinhäuser, Christian; Bedner, Peter

in Glia (2023), 71(2), 168-186

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2022

Full Text
See detailSoluble TAM receptors sAXL and sTyro3 predict structural and functional protection in Alzheimer's disease.
Brosseron, Frederic; Maass, Anne; Kleineidam, Luca; Ravichandran, Kishore Aravind; González, Pablo García; McManus, Róisín M.; Ising, Christina; Santarelli, Francesco; Kolbe, Carl-Christian; Häsler, Lisa M.; Wolfsgruber, Steffen; Marquié, Marta; Boada, Mercè; Orellana, Adelina; de Rojas, Itziar; Röske, Sandra; Peters, Oliver; Cosma, Nicoleta-Carmen; Cetindag, Arda; Wang, Xiao; Priller, Josef; Spruth, Eike J.; Altenstein, Slawek; Schneider, Anja; Fliessbach, Klaus; Wiltfang, Jens; Schott, Björn H.; Bürger, Katharina; Janowitz, Daniel; Dichgans, Martin; Perneczky, Robert; Rauchmann, Boris-Stephan; Teipel, Stefan; Kilimann, Ingo; Goerss, Doreen; Laske, Christoph; Munk, Matthias H.; Düzel, Emrah; Yakupov, Renat; Dobisch, Laura; Metzger, Coraline D.; Glanz, Wenzel; Ewers, Michael; Dechent, Peter; Haynes, John Dylan; Scheffler, Klaus; Roy, Nina; Rostamzadeh, Ayda; Teunissen, Charlotte E.; Marchant, Natalie L.; Spottke, Annika; Jucker, Mathias; Latz, Eicke; Wagner, Michael; Mengel, David; Synofzik, Matthis; Jessen, Frank; Ramirez, Alfredo; Ruiz, Agustín; Heneka, Michael

in Neuron (2022), 110(6), 1009-10224

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See detailCNS Superficial Siderosis Mimicking a Motor Neuron Disease.
Castro-Gomez, Sergio; Binder, Julius; Schievelkamp, Arndt-Hendrik; Heneka, Michael

in Brain sciences (2022), 12(11),

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See detailMicroglia states and nomenclature: A field at its crossroads.
Paolicelli, Rosa C.; Sierra, Amanda; Stevens, Beth; Tremblay, Marie-Eve; Aguzzi, Adriano; Ajami, Bahareh; Amit, Ido; Audinat, Etienne; Bechmann, Ingo; Bennett, Mariko; Bennett, Frederick; Bessis, Alain; Biber, Knut; Bilbo, Staci; Blurton-Jones, Mathew; Boddeke, Erik; Brites, Dora; Brône, Bert; Brown, Guy C.; Butovsky, Oleg; Carson, Monica J.; Castellano, Bernardo; Colonna, Marco; Cowley, Sally A.; Cunningham, Colm; Davalos, Dimitrios; De Jager, Philip L.; de Strooper, Bart; Denes, Adam; Eggen, Bart J. L.; Eyo, Ukpong; Galea, Elena; Garel, Sonia; Ginhoux, Florent; Glass, Christopher K.; Gokce, Ozgun; Gomez-Nicola, Diego; González, Berta; Gordon, Siamon; Graeber, Manuel B.; Greenhalgh, Andrew D.; Gressens, Pierre; Greter, Melanie; Gutmann, David H.; Haass, Christian; Heneka, Michael; Heppner, Frank L.; Hong, Soyon; Hume, David A.; Jung, Steffen; Kettenmann, Helmut; Kipnis, Jonathan; Koyama, Ryuta; Lemke, Greg; Lynch, Marina; Majewska, Ania; Malcangio, Marzia; Malm, Tarja; Mancuso, Renzo; Masuda, Takahiro; Matteoli, Michela; McColl, Barry W.; Miron, Veronique E.; Molofsky, Anna Victoria; Monje, Michelle; Mracsko, Eva; Nadjar, Agnes; Neher, Jonas J.; Neniskyte, Urte; Neumann, Harald; Noda, Mami; Peng, Bo; Peri, Francesca; Perry, V. Hugh; Popovich, Phillip G.; Pridans, Clare; Priller, Josef; Prinz, Marco; Ragozzino, Davide; Ransohoff, Richard M.; Salter, Michael W.; Schaefer, Anne; Schafer, Dorothy P.; Schwartz, Michal; Simons, Mikael; Smith, Cody J.; Streit, Wolfgang J.; Tay, Tuan Leng; Tsai, Li-Huei; Verkhratsky, Alexei; von Bernhardi, Rommy; Wake, Hiroaki; Wittamer, Valérie; Wolf, Susanne A.; Wu, Long-Jun; Wyss-Coray, Tony

in Neuron (2022), 110(21), 3458-3483

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