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See detailPARK7/DJ-1 promotes pyruvate dehydrogenase activity and maintains T(reg) homeostasis during ageing.
Danileviciute, Egle; Zeng, Ni; Capelle, Christophe M.; Paczia, Nicole; Gillespie, Mark A.; Kurniawan, Henry; Benzarti, Mohaned; Merz, Myriam P.; Coowar, Djalil; Fritah, Sabrina; Vogt Weisenhorn, Daniela Maria; Gomez Giro, Gemma; Grusdat, Melanie; Baron, Alexandre; Guerin, Coralie; Franchina, Davide G.; Léonard, Cathy; Domingues, Olivia; Delhalle, Sylvie; Wurst, Wolfgang; Turner, Jonathan; Schwamborn, Jens Christian; Meiser, Johannes; Krüger, Rejko; Ranish, Jeff; Brenner, Dirk; Linster, Carole; Balling, Rudi; Ollert, Markus; He, Feng

in Nature metabolism (2022), 4(5), 589-607

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See detailAn archaeal compound as a driver of Parkinson’s disease pathogenesis
Trezzi, Jean-Pierre; Aho, Velma; Jäger, Christian; Schade, Sebastian; Janzen, Annette; Hickl, Oskar; Kunath, Benoit; Thomas, Melanie; Schmit, Kristopher; Garcia, Pierre; Sciortino, Alessia; Martin-Gallausiaux, Camille; Halder, Rashi; Huarte, Oihane Uriarte; Heurtaux, Tony; Heins-Marroquin, Ursula; Gomez-Giro, Gemma; Weidenbach, Katrin; Delacour, Lea; Laczny, Cedric Christian; Novikova, Polina; Ramiro-Garcia, Javier; Singh, Randolph; Andújar, Begoña Talavera; Lebrun, Laura; Daujeumont, Annegrait; Habier, Janine; Dong, Xiangyi; Gavotto, Floriane; Heintz-Buschart, Anna; Schneider, Jochen; Jehmlich, Nico; Bergen, Martin Von; Schymanski, Emma; Schmitz, Ruth; Schwamborn, Jens Christian; Glaab, Enrico; Linster, Carole; Kitami, Toshimori; Buttini, Manuel; May, Patrick; Trenkwalder, Claudia; Oertel, Wolfgang; Mollenhauer, Brit; Wilmes, Paul

E-print/Working paper (2022)

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See detailRegulation of N6-Methyladenosine after Myocardial Infarction
Vausort, Mélanie; Niedolistek, Magdalena; Lumley, Andrew I.; Oknińska, Marta; Paterek, Aleksandra; Mączewski, Michał; Dong, Xiangyi; Jäger, Christian; Linster, Carole; Leszek, Przemyslaw; Devaux, Yvan

in Cells (2022), 11(15), 2271

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See detailMolecular ruler mechanism and interfacial catalysis of the integral membrane acyltransferase PatA
Anso, Itxaso; Basso, Luis G. M.; Wang, Lei; Marina, Alberto; Páez-Pérez, Edgar D.; Jäger, Christian; gavotto, Floriane; Tersa, Montse; Perrone, Sebastian; Contreras, F.-Xabier; Prandi, Jacques; Gilleron, Martine; Linster, Carole; Corzana, Francisco; Lowary, Todd L.; Trastoy, Beatriz; Guerin, Marcelo E.

in Science Advances (2021), 7(42),

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See detailApproaches for completing metabolic networks through metabolite damage and repair discovery
Griffith, Corey; Walvekar, Adhish; Linster, Carole

in Current Opinion in Systems Biology (2021), 28

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See detailThe metalloprotein YhcH is an anomerase providing N-acetylneuraminate aldolase with the open form of its substrate
Kentache, Takfarinas; Thabault, Leopold; Deumer, Gladys; Haufroid, Vincent; Frédéerick, Raphael; Linster, Carole; Peracchi, Alessio; Veiga-da-Cunha, Maria; Bommer, Guido; van Schaftingen, Emile

in Journal of Biological Chemistry (2021)

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See detailThe Role of DJ-1 in Cellular Metabolism and Pathophysiological Implications for Parkinson’s Disease
Mencke, Pauline; Boussaad, Ibrahim; Romano, Chiara; Kitami, Toshimori; Linster, Carole; Krüger, Rejko

in Cells (2021)

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See detailL-Isoaspartyl methyltransferase deficiency in zebrafish leads to impaired calcium signaling in the brain
Soliman, Remon; Cordero Maldonado, Maria Lorena; Martins, Teresa; Moein, Mahsa; Conrotte, Jean-François; Warmack, Rebeccah; Skupin, Alexander; Crawford, Alexander; Clarke, Steven; Linster, Carole

in Frontiers in Genetics (2020)

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See detailReply: NAD(P)HX dehydratase protein-truncating mutations are associated with neurodevelopmental disorder exacerbated by acute illness
Van Bergen, Nicole J.; Linster, Carole; Christodoulou, John

in Brain: a Journal of Neurology (2020), 143(7), 55

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See detailPhenotypic assays in yeast and zebrafish reveal drugs that rescue ATP13A2 deficiency
Heins Marroquin, Ursula; Jung, Paul; Cordero Maldonado, Maria Lorena; Crawford, Alexander; Linster, Carole

in Brain Communications (2019), 1(1), 2-17

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See detail3‑Phosphoglycerate Transhydrogenation Instead of Dehydrogenation Alleviates the Redox State Dependency of Yeast de Novo L‑Serine Synthesis
Paczia, Nicole; Becker-Kettern, Julia; Conrotte, Jean-François; Cifuente, Javier O.; Guerin, Marcelo E.; Linster, Carole

in Biochemistry (2019)

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See detailConnecting environmental exposure and neurodegeneration using cheminformatics and high resolution mass spectrometry: potential and challenges
Schymanski, Emma; Baker, Nancy C.; Williams, Antony J; Singh, Randolph; Trezzi, Jean-Pierre; Kolber, Pierre Luc; Wilmes, Paul; Krüger, Rejko; Paczia, Nicole; Linster, Carole; Balling, Rudi

in Environmental Science. Processes and Impacts (2019)

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See detailNAD(P)HX dehydratase (NAXD) deficiency: a novel neurodegenerative disorder exacerbated by febrile illnesses
Van Bergen, Nicole; Guo, Yiran; Rankin, Julia; Paczia, Nicole; Becker-Kettern, Julia; Kremer, Laura; Pyle, Angela; Conrotte, Jean-François; Ellaway, Carolyn; Procopis, Peter; Prelog, Kristina; Homfray, Tessa; Baptista, Júlia; Baple, Emma; Wakeling, Matthew; Massey, Sean; Kay, Daniel; Shukla, Anju; Girisha, Katta; Lewis, Leslie; Santra, Saikat; Power, Rachel; Daubeney, Piers; Montoya, Julio; Ruiz-Pesini; Kovacs-Nagy, Reka; Pritsch, Martin; Ahting, Uwe; Thorburn, David; Prokisch, Holger; Taylor, Robert; Christodoulou, John; Linster, Carole; Ellard, Sian; Hakonarson, Hakon

in Brain: a Journal of Neurology (2019), 142(1), 50-58

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See detailFailure to eliminate a phosphorylated glucose analog leads to neutropenia in patients with G6PT and G6PC3 deficiency
Veiga-da-Cunha, Maria; Chevalier, Nathalie; Stephenne, Xavier; Defour, Jean-Philippe; Paczia, Nicole; Ferster, Alina; Achouri, Younes; Dewulf, Joseph P; Linster, Carole; Bommer, Guido T; Van Schaftingen, Emile

in Proceedings of the National Academy of Sciences of the United States of America (2019), 116(4), 1241-1250

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See detailBSA4Yeast: Web-based quantitative trait locus linkage analysis and bulk segregant analysis of yeast sequencing data
Zhang, Zhi; Jung, Paul; Groues, Valentin; May, Patrick; Linster, Carole; Glaab, Enrico

in GigaScience (2019), 8(6), 060

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See detailNAD(P)HX repair deficiency causes central metabolic perturbations in yeast and human cells
Becker-Kettern, Julia; Paczia, Nicole; Conrotte, Jean-François; Zhu, Chenchen; Fiehn, Oliver; Jung, Paul; Steinmetz, Lars; Linster, Carole

in FEBS Journal (2018)

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See detailMillifluidic culture improves human midbrain organoid vitality and differentiation
Berger, Emanuel; Magliaro, Chiara; Paczia, Nicole; Monzel, Anna Sophia; Antony, Paul; Linster, Carole; Bolognin, Silvia; Ahluwalia, Arti; Schwamborn, Jens Christian

in Lab on a Chip - Miniaturisation for Chemistry and Biology (2018)

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See detailNatural variation of chronological aging in the Saccharomyces cerevisiae species reveals diet-dependent mechanisms of life span control
Jung, Paul; Zhang, Zhi; Paczia, Nicole; Jäger, Christian; Ignac, Tomasz; May, Patrick; Linster, Carole

in npj Aging and Mechanisms of Disease (2018), 4(3),

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See detailConfronting the catalytic dark matter encoded by sequenced genomes
Ellens, Kenneth W.; Christian, Nils; Satagopam, Venkata; May, Patrick; Linster, Carole

in Nucleic Acids Research (2017), 45(20), 11495-11514

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See detailNit1 is a metabolite repair enzyme that hydrolyzes deaminated glutathione
Peracchi, Alessio; Veiga-da-Cunha, Maria; Kuhara, Tomiko; Ellens, Kenneth W; Paczia, Nicole; Stroobant, Vincent; Seliga, Agnieszka K; Marlaire, Simon; Jaisson, Stephane; Bommer, Guido T; Sun, Jin; Huebner, Kay; Linster, Carole; Cooper, Arthur J.L.; Van Schaftingen, Emile

in Proceedings of the National Academy of Sciences of the United States of America (2017), 1613736114

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See detailMolecular Identification of D-Ribulokinase in Budding Yeast and Mammals
Singh, Charandeep; Glaab, Enrico; Linster, Carole

in Journal of Biological Chemistry (2017), 292(3), 1005-1028

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See detailSaccharomyces cerevisiae Forms D-2-Hydroxyglutarate and Couples its Degradation to D-Lactate Formation via a Cytosolic Transhydrogenase.
Becker-Kettern, Julia; Paczia, Nicole; Conrotte, Jean-Francois; Kay, Daniel; Guignard, Cedric; Jung, Paul; Linster, Carole

in The Journal of Biological Chemistry (2016)

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See detailA conserved phosphatase destroys toxic glycolytic side products in mammals and yeast
Collard, François; Baldin, Francesca; Gerin, Isabelle; Bolsée, Jennifer; Noël, Gaëtane; Graff, Julie; Veiga-da-Cunha, Maria; Stroobant, Vincent; Vertommen, Didier; Houddane, Amina; Rider, Mark H; Linster, Carole; Van Schaftingen, Emile; Bommer, Guido T

in Nature Chemical Biology (2016), 12(8), 601-607

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See detailProtocols and programs for high-throughput growth and aging phenotyping in yeast.
Jung, Paul; Christian, Nils; Kay, Daniel; Skupin, Alexander; Linster, Carole

in PloS one (2015), 10(3), 0119807

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See detailEnzyme complexity in intermediary metabolism.
Van Schaftingen, Emile; Veiga-da-Cunha, Maria; Linster, Carole

in Journal of inherited metabolic disease (2015), 38(4), 721-7

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See detailOccurrence and subcellular distribution of the NAD(P)HX repair system in mammals.
Marbaix, Alexandre Y.; Tyteca, Donatienne; Niehaus, Tom D.; Hanson, Andrew D.; Linster, Carole; Van Schaftingen, Emile

in The Biochemical journal (2014), 460(1), 49-58

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See detailMetabolite damage and its repair or pre-emption
Linster, Carole; Van Schaftingen, E.; Hanson, A. D.

in Nature Chemical Biology (2013), 9(2), 72-80

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See detailImmune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production
Michelucci, Alessandro; Cordes, Thekla; Ghelfi, Jenny; Pailot, Arnaud; Reiling, Norbert; Goldmann, Oliver; Binz, Tina; Wegner, André; Tallam, Aravind; Rausell, Antonio; Buttini, Manuel; Linster, Carole; Medina, Eva; Balling, Rudi; Hiller, Karsten

in Proceedings of the National Academy of Sciences of the United States of America (2013)

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See detailMetabolite proofreading, a neglected aspect of intermediary metabolism
Van Schaftingen, E.; Rzem, R.; Marbaix, A.; Collard, F.; Veiga-da-Cunha, M.; Linster, Carole

in Journal of Inherited Metabolic Disease (2013), 36(3), 427-34

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See detailImpact of oxidative stress on ascorbate biosynthesis in Chlamydomonas via regulation of the VTC2 gene encoding a GDP-L-galactose phosphorylase
Urzica, E. I.; Adler, Lital N.; Page, M. D.; Linster, Carole; Arbing, M. A.; Casero, D.; Pellegrini, M.; Merchant, S. S.; Clarke, S. G.

in Journal of Biological Chemistry (2012), 287(17), 14234-45

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See detailA novel GDP-D-glucose phosphorylase involved in quality control of the nucleoside diphosphate sugar pool in Caenorhabditis elegans and mammals
Adler, Lital N.; Gomez, Tara A.; Clarke, Steven G.; Linster, Carole

in Journal of Biological Chemistry (2011), 286(24), 21511-23

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See detailEthylmalonyl-CoA decarboxylase, a new enzyme involved in metabolite proofreading
Linster, Carole; Noël, Gaëtane; Stroobant, Vincent; Vertommen, Didier; Vincent, Marie-Françoise; Bommer, Guido T.; Veiga-da-Cunha, Maria; Van Schaftingen, Emile

in Journal of Biological Chemistry (2011), 286(50), 42992-3003

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See detailExtremely conserved ATP- or ADP-dependent enzymatic system for nicotinamide nucleotide repair
Marbaix, Alexandre Y.; Noël, Gaëtane; Detroux, Aline M.; Vertommen, Didier; Van Schaftingen, Emile; Linster, Carole

in Journal of Biological Chemistry (2011), 286(48), 41246-52

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See detailDefective responses to oxidative stress in protein l-isoaspartyl repair-deficient Caenorhabditis elegans
Khare, Shilpi; Gomez, Tara; Linster, Carole; Clarke, Steven G.

in Mechanisms of Ageing and Development (2009), 130(10), 670-80

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