Key Publications

1. Kurniawan H, Franchina DG, Guerra L, Bonetti L, Soriano-Baguet L, Grusdat M, Schlicker L, Hunewald O, Dostert C, Merz MP, Binsfeld C, Duncan GS, Farinelle S, Ewen A, Nonnenmacher Y, Haight J, Das Gupta D, Taskesen R, Halder R, Chen Y, Jäger C, Ollert M, Wilmes P, Vasiliou V, Harris IS, Knobbe-Thomsen C, Turner JD, Mak TW, Lohoff M, Meiser J, Hiller K, Brenner D. Glutathione restricts serine metabolism to preserve regulatory T cell function. Cell Metabolism, 2020 May;31(5):920-936e7. doi: 10.1016/j.cmet.2020.03.004

2. Cox MA, Duncan GS, Lin GYH, Steinberg BE, Yu LX, Brenner D, Buckler LN, Elia AJ, Wakeham AC, Nieman B, Dominguez-Brauer C, Elford AR, Gill KT, Kubli SP, Haight J, Berger T, Ohashi PS, Tracey KJ, Olofsson PS, Mak TW. Choline acetyltransferase-expressing T cells are required to control chronic viral infection. Science, 2019 Feb 8;363(6427):639-644. doi: 10.1126/science.aau9072

3. Mak TW, Grusdat M, Duncan GS, Dostert C, Nonnenmacher Y, Cox M, Binsfeld C, Hao Z, Brüstle A, Itsumi M, Jäger C, Chen Y, Pinkenburg O, Camara B, Ollert M, Bindslev-Jensen C, Vasiliou V, Gorrini C, Lang PA, Lohoff M, Harris IS, Hiller K, Brenner D. Glutathione Primes T cell metabolism for Inflammation. Immunity, 2017 Apr 18;46(4):675-689. doi: 10.1016/j.immuni.2017.06.009

4. Brenner D, Blaser H, Mak TW. TNF regulation: Live or Let Die. Nature Reviews Immunology, 2015 Jun;15(6):362-74. doi: 10.1038/nri3834

5. Harris IS, Treloar AE, Sasaki M, Inoue S, Gorrini C, Lee KC, Yung KY, Brenner D, Knobbe CB, Adeoye , Brüstle A, Molyneux SD, Elia A, Berger T, Mason JM, Blaser H, Berman HK, Wakeham A, Khokha R, Done S, Kavanagh TJ, Lam CW, Mak TW. Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression. Cancer Cell, 2015 Feb 9;27(2):211-22. doi: 10.1016/j.ccell.2014.11.019 

6. Sasaki M, Knobbe CB, Munger JC, Lind EF, Brenner D, Brüstle A, Harris IS, Holmes R, Wakeham A, Haight J, You-Ten A, Li WY, Virtanen C, Reifenberger G, Ohashi PS, Barber DL, Figueroa MF, Melnick A, Zuniga-Pflücker JC, Mak TW. IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics. Nature, 2012 Aug 30;488(7413):656-9. doi: 10.1038/nature11323