Prof. Dr. Iris Behrmann

Iris Behrmann

Full professor en Biochimie

Forschungsthemen Biochemistry, Cytokine Signal Transduction
Fakultät oder Zentrum Fakultät für Naturwissenschaften, Technologie und Medizin
Department Fachbereich Lebenswissenscha​ften und Medizin
Postadresse Université du Luxembourg
6, avenue du Swing
L-4367 Belvaux
Büroadresse BioTech II, 4.26
E-Mail
Telefon (+352) 46 66 44 6740

Position

Last updated on: Dienstag, den 22. Oktober 2019

Academic Qualifications

  • Diploma in Biology, Universität Bielefeld, Germany, 1990
  • PhD (Dr. rer. nat.), Universität Bielefeld, Germany, 1992 (thesis at the German Cancer Research Center, Heidelberg)
  • Habilitation, venia legendi in Biochemistry, RWTH-Aachen Medical School, Germany, 2001



Last updated on: 29 Jan 2010

Research Interests

  • molecular mechanisms of cytokine signal transduction,
  • (patho)physiologic consequences of Jak/STAT signalling, e. g. the role of constitutively active Jak mutants in myeloproliferative neoplasms,
  • microRNAs in melanoma development and growth regulation,
  • cross-talk of cytokine signal transduction with other signalling pathways (hypoxia, growth factors).



Last updated on: 29 Jan 2010

powered by
orbilu.uni.lu

2019

Full Text
See detailmiR-873-5p targets mitochondrialGNMT-Complex II interface contributing tonon-alcoholic fatty liver disease
Fernández-Tussy, Pablo; Fernández-Ramos, David; Lopitz-Otsoa, Fernando; Simón, Jorge; Barbier-Torres, Lucía; Gomez-Santos, Beatriz; Nuñez-Garcia, Maitane; Azkargorta, Mikel; Gutiérrez-de Juan, Virginia; Serrano-Macia, Marina; Rodríguez-Agudo, Rubén; Iruzubieta, Paula; Anguita, Juan; Castro, Rui Eduardo; Champagne, Devin; Rincón, Mercedes; Elortza, Felix; Arslanow, Anita; Krawczyk, Marcin; Lammert, Frank; Kirchmeyer, Mélanie; Behrmann, Iris; Crespo, Javier; Lu, Shelly; Mato, José; Varela-Rey, Marta; Aspichueta, Patricia; Cardoso Delgado, Teresa; Martinez_Chantar, Maria

in Molecular Metabolism (2019)

Full Text
See detailModulation of the IL-6 signaling pathway in liver cells by miRNAs targeting gp130, JAK1 and/or STAT3
Servais, Florence; Kirchmeyer, Mélanie; Hamdorf, Matthias; Minoungou, Wendkouni Nadège; Rose-John, Stefan; Kreis, Stephanie; Haan, Claude; Behrmann, Iris

in Molecular Therapy: Nucleic Acids (2019), 16

Top of Page

2018

Full Text
See detailCytokine-mediated modulation of the hepatic miRNome: miR-146b-5p is an IL-6-inducible miRNA with multiple targets.
Kirchmeyer, Melanie; Servais, Florence; Hamdorf, Matthias; Nazarov, Petr V.; Ginolhac, Aurélien; Halder, Rashi; Vallar, Laurent; Glanemann, Matthias; Rubie, Claudia; Lammert, Frank; Kreis, Stephanie; Behrmann, Iris

in Journal of leukocyte biology (2018)

Full Text
See detailThe PD-L1- and IL6-mediated dampening of the IL27/STAT1 anticancer responses are prevented by a-PD-L1 or a-IL6 antibodies
Rolvering, Catherine; Zimmer, Andreas David; Ginolhac, Aurélien; Margue, Christiane; Kirchmeyer, Mélanie; Servais, Florence; Hermanns, Heike M.; Hergovits, Sabine; Nazarov, Petr V.; Nicot, Nathalie; Kreis, Stephanie; Haan, Serge; Behrmann, Iris; Haan, Claude

in Journal of Leukocyte Biology (2018), 104

Top of Page

2017

Full Text
See detailThe multi-site docking protein Gab1 is constitutively phosphorylated independent from its recruitment to the plasma membrane in Jak2-V617Fpositive cells and mediates proliferation of human erythroleukaemia cells
Bongartz, Hannes; Hessenkemper, Wiebke; Müller, Christian; Fensky, Melissa; Fritsch, Johannes; Mandel, Katharina; Behrmann, Iris; Haan, Claude; Fischer, Thomas; Feller, Stephan M.; Schaper, Fred

in Cellular Signalling (2017), 35

Full Text
See detailCrosstalk between different family members: IL27 recapitulates IFNγ responses in HCC cells, but is inhibited by IL6-type cytokines
Rolvering, Catherine; Zimmer, Andreas; Kozar, Ines; Hermanns; Letellier, Elisabeth; Vallar, Laurent; Nazarov, Petr; Nicot, Nathalie; Ginolhac, Aurélien; Haan, Serge; Behrmann, Iris; Haan, Claude

in BBA Molecular Cell Research (2017)

Top of Page

2016

Full Text
See detailThe role of HIF-1 in oncostatin M-dependent metabolic reprogramming of hepatic cells.
Battello, Nadia; Zimmer, Andreas David; Goebel, Carole; Dong, Xiangyi; Behrmann, Iris; Haan, Claude; Hiller, Karsten; Wegner, Andre

in Cancer & metabolism (2016), 4

Full Text
See detailVariant PNPLA3 increases the HCC risk: prospective study in patients treated at the Saarland University Medical Center
Casper, Markus; Krawczyk, Marcin; Behrmann, Iris; Glanemann, Matthias; Lammert, Frank

in Zeitschrift für Gastroenterologie (2016), 54

Full Text
See detailPhosphorylation of the PDH complex precedes HIF-1-mediated effects and PDK1 upregulation during the first hours of hypoxic treatment in HCC cells
Zimmer, Andreas David; Walbrecq, Geoffroy; Kozar, Ines; Behrmann, Iris; Haan, Claude

in Hypoxia (2016), 4

Top of Page

2015

Full Text
See detailCirculating microRNAs as candidate biomarkers for the surveillance of melanoma patients
Behrmann, Iris; Margue, Christiane; Kreis, Stephanie

in EBioMedicine (2015)

Full Text
See detailComparison of a healthy miRNome with melanoma patient miRNomes: are microRNAs suitable serum biomarkers for cancer?
Margue, Christiane; Reinsbach, Susanne; Philippidou, Demetra; Beaume, Nicolas; Walters, Casandra; Schneider, Jochen; Nashan, Dorothee; Behrmann, Iris; Kreis, Stephanie

in Oncotarget (2015), 6(14), 12110-27

Full Text
See detailID: 194: Role of microRNAs in signal transduction pathways of the inflammatory cytokine Interleukin-6: Relevance for liver diseases
Servais, Florence; Kirchmeyer, Mélanie; Hamdorf, Matthias; Haan, Claude; Casper, Markus; Lammert, Frank; Nazarov, Petr; Vallar, Laurent; Kreis, Stephanie; Behrmann, Iris

in Cytokine (2015), 76(1), 99-

Top of Page

2013

Full Text
See detailJAK2 mutants (e.g., JAK2V617F) and their importance as drug targets in myeloproliferative neoplasms
Gäbler, Karoline; Behrmann, Iris; Haan, Claude

in JAK-STAT (2013), 2(3), 25025

Full Text
See detailCooperative effects of Janus and Aurora kinase inhibition by CEP701 in cells expressing Jak2V617F
Gäbler, Karoline; Rolvering, Catherine; Kaczor, Jakub; Eulenfeld, R.; Méndez, S. A.; Berchem, G.; Palissot, V.; Behrmann, Iris; Haan, Claude

in Journal of Cellular & Molecular Medicine (2013), 17(2), 265-276

Full Text
See detailNew Target Genes of MITF-Induced microRNA-211 Contribute to Melanoma Cell Invasion
Margue, Christiane; Philippidou, Demetra; Reinsbach, Susanne; Schmitt, Martina; Behrmann, Iris; Kreis, Stephanie

in PLoS ONE (2013), 8(9),

Full Text
See detailJAK2-V617F-induced MAPK activity is regulated by PI3K and acts synergistically with PI3K on the proliferation of JAK2-V617F-positive cells.
Wolf, Alexandra; Eulenfeld, Rene; Gäbler, Karoline; Rolvering, Catherine; Haan, Serge; Behrmann, Iris; Denecke, Bernd; Haan, Claude; Schaper, Fred

in JAK-STAT (2013), 2(3), 24574

Top of Page

2012

Full Text
See detailDynamic regulation of microRNA expression following interferonγ- induced gene transcription
Reinsbach, Susanne; Nazarov, Petr V.; Philippidou, Demetra; Schmitt, Martina; Wienecke, Anke; Muller, Arnaud; Vallar, Laurent; Behrmann, Iris; Kreis, Stephanie

in RNA Biology (2012), 9(7), 987-989

Full Text
See detailInterferon-γ-induced activation of Signal Transducer and Activator of Transcription 1 (STAT1) up-regulates the tumor suppressing microRNA-29 family in melanoma cells
Schmitt, Martina J.; Philippidou, Demetra; Reinsbach, Susanne; Margue, Christiane; Wienecke-Baldacchino, Anke; Nashan, Dorothee; Behrmann, Iris; Kreis, Stephanie

in Cell Communication and Signaling (2012), 10

Full Text
See detailMiRNA-29: A microRNA family with tumor-suppressing and immune-modulating properties
Schmitt, Martina; Margue, Christiane; Behrmann, Iris; Kreis, Stephanie

in Current Molecular Medicine (2012), 13(4), 572-585

Top of Page

2011

Full Text
See detailJak1 has a dominant role over Jak3 in signal transduction through γc-containing cytokine receptors
Haan, Claude; Rolvering, Catherine; Raulf, F.; Kapp, M.; Drückes, P.; Thoma, G.; Behrmann, Iris; Zerwes, H.-G.

in Chemistry & Biology (2011), 18(3), 314-323

Top of Page

2010

Full Text
See detailSignal transduction, receptors, mediators and genes: Younger than ever - The 13th meeting of the Signal Transduction Society focused on aging and immunology
Entschladen, F.; Altschmied, J.; Baumgrass, R.; Behrmann, Iris; Giehl, K.; Hermanns, H.; Huber, O.; Kieser, A.; Klotz, L.-O.; Kubatzky, K. F.; Hass, R.; Janssen, O.; Friedrich, K.

in Cell Communication and Signaling (2010), 8

Full Text
See detailPerspectives for the use of structural information and chemical genetics to develop inhibitors of Janus kinases.
Haan, Claude; Behrmann, Iris; Haan, Serge

in Journal of Cellular & Molecular Medicine (2010), 14(3), 504-27

Full Text
See detailSignatures of MicroRNAs and selected MicroRNA target genes in human melanoma
Philippidou, Demetra; Schmitt, Martina; Moser, Dirk; Margue, Christiane; Nazarov, Petr V.; Muller, Arnaud; Vallar, Laurent; Nashan, Dorothee; Behrmann, Iris; Kreis, Stephanie

in Cancer Research (2010), 70(10), 4163-4173

Full Text
See detailCross-regulation of cytokine signalling: Pro-inflammatory cytokines restrict IL-6 signalling through receptor internalisation and degradation
Radtke, S.; Wüller, S.; Yang, X.-P.; Lippok, B. E.; Mütze, B.; Mais, C.; Schmitz-Van De Leur, H.; Bode, J. G.; Gaestel, M.; Heinrich, P. C.; Behrmann, Iris; Schaper, F. A; Hermanns, H. M.

in Journal of Cell Science (2010), 123(6), 947-959

Full Text
See detailOncostatin M up-regulates the ER chaperone Grp78/BiP in liver cells
Vollmer, Stefan; Haan, Claude; Behrmann, Iris

in Biochemical Pharmacology (2010), 80(12), 2066-2073

Top of Page

2009

See detailZelluläre Signalprozesse
Friedrich, Karlheinz; Behrmann, Iris

in Biochemie und Molekularbiologie des Menschen (2009)

Full Text
See detailAn unusual insertion in Jak2 is crucial for kinase activity and differentially affects cytokine responses
Haan, Claude; Kroy, Daniela C.; Wüller, Stefan; Sommer, Ulrike; Nöcker, Tanja; Rolvering, Catherine; Behrmann, Iris; Heinrich, Peter C.; Haan, Serge

in Journal of Immunology (2009), 182(5), 2969-2977

Full Text
See detailSOCS-mediated downregulation of mutant Jak2 (V617F, T875N and K539L) counteracts cytokine-independent signaling.
Haan, Serge; Wuller, S.; Kaczor, Jakub; Rolvering, Catherine; Nocker, T.; Behrmann, Iris; Haan, Claude

in Oncogene (2009), 28(34), 3069-80

Full Text
See detailHypoxia-inducible factor 1alpha is up-regulated by oncostatin M and participates in oncostatin M signaling
Vollmer, Stefan; Kappler, Valérie; Kaczor, Jakub; Flügel, Daniela; Rolvering, Catherine; Kato, Nobuyuki; Kietzmann, Thomas; Behrmann, Iris; Haan, Claude

in Hepatology (Baltimore, Md.) (2009), 2009(3),

Top of Page

2008

See detailDual role of the Jak1 FERM and kinase domains in cytokine receptor binding and in stimulation-dependent Jak activation
Haan, Serge; Margue, Christiane; Engrand, A.; Rolvering, Catherine; Schmitz-Van de Leur, H.; Heinrich, P. C.; Behrmann, Iris; Haan, Claude

in Journal of Immunology (2008), 180(2), 998-1007

Full Text
See detailCell density dependent increase of constitutive signal transducers and activators of transcription 3 activity in melanoma cells is mediated by Janus kinases
Kreis, Stephanie; Munz, George. A.; Haan, Serge; Heinrich, Peter. C.; Behrmann, Iris

in Molecular Cancer Research (2008), 5(12), 1331-41

Full Text
See detailIL-24: a classic cytokine and/or a potential cure for cancer?
Kreis, Stephanie; Philippidou, Demetra; Margue, Christiane; Behrmann, Iris

in Journal of Cellular & Molecular Medicine (2008), 12(6A), 2505-2510

Top of Page

2007

Full Text
See detailA cost effective non-commercial ECL-solution for Western blot detections yielding strong signals and low background
Haan, Claude; Behrmann, Iris

in Journal of Immunological Methods (2007), 318(1-2), 11-9

See detailConstitutive suppressor of cytokine signaling 3 expression confers a growth advantage to a human melanoma cell line
Komyod, W.; Böhm, M.; Metze, D.; Heinrich, P. C.; Behrmann, Iris

in Molecular Cancer Research (2007), 5(3), 271-81

Full Text
See detailRecombinant interleukin-24 lacks apoptosis-inducing properties in melanoma cells
Kreis, Stephanie; Philippidou, Demetra; Margue, Christiane; Rolvering, Catherine; Haan, Claude; Dumoutier, Laure; Renauld, Jean-Christophe; Behrmann, Iris

in PLoS ONE (2007), 2(12), 1300

See detailSTAT1 regulates p73-mediated Bax gene expression
Soond, S. M.; Carroll, C.; Townsend, P. A.; Sayan, E.; Melino, G.; Behrmann, Iris; Knight, R. A.; Latchman, D. S.; Stephanou, A.

in FEBS Letters (2007), 581(6), 1217-26

Top of Page

2006

Full Text
See detailJaks and cytokine receptors - an intimate relationship
Haan, Claude; Kreis, Stephanie; Margue, Christiane; Behrmann, Iris

in Biochemical Pharmacology (2006), 72(11), 1538-46

See detailThree dileucine-like motifs within the interbox1/2 region of the human oncostatin M receptor prevent efficient surface expression in the absence of an associated Janus kinase
Radtke, S.; Jörissen, A.; de Leur, H. S.; Heinrich, P. C.; Behrmann, Iris

in Journal of Biological Chemistry (2006), 281(7), 4024-34

See detailBiological responses to PDGF-BB versus PDGF-DD in human mesangial cells
van Roeyen, C. R.; Ostendorf, T.; Denecke, B.; Bokemeyer, D.; Behrmann, Iris; Strutz, F.; Lichenstein, H. S.; LaRochelle, W. J.; Pena, C. E.; Chaudhuri, A.; Floege, J.

in Kidney International (2006), 69(8), 1393-402

Top of Page

2005

See detailMultiple reasons for an inefficient STAT1 response upon IL-6-type cytokine stimulation
Haan, Serge; Keller, J. F.; Behrmann, Iris; Heinrich, P. C.; Haan, Claude

in Cellular Signalling (2005), 17(12), 1542-50

See detailPromoter-hypermethylation is causing functional relevant downregulation of methylthioadenosine phosphorylase (MTAP) expression in hepatocellular carcinoma
Hellerbrand, C.; Mühlbauer, M.; Wallner, S.; Schuierer, M.; Behrmann, Iris; Bataille, F.; Weiss, T.; Schölmerich, J.; Bosserhoff, A. K.

in Carcinogenesis (2005), 27(1), 64-72

See detailAre STATS arginine-methylated?
Komyod, W.; Bauer, U. M.; Heinrich, P. C.; Haan, Serge; Behrmann, Iris

in Journal of Biological Chemistry (2005), 280(23), 21700-5

See detailThe Jak1 SH2 domain does not fulfill a classical SH2 function in Jak/STAT signaling but plays a structural role for receptor interaction and up-regulation of receptor surface expression
Radtke, S.; Haan, Serge; Jörissen, A.; Hermanns, H. M.; Diefenbach, S.; Smyczek, T.; Schmitz-Vandeleur, H.; Heinrich, P. C.; Behrmann, Iris; Haan, Claude

in Journal of Biological Chemistry (2005), 280(27), 25760-8

See detailSTAT5 contributes to interferon resistance of melanoma cells
Wellbrock, C.; Weisser, C.; Hassel, J. C.; Fischer, P.; Becker, J.; Vetter, C. S.; Behrmann, Iris; Kortylewski, M.; Heinrich, P. C.; Schartl, M.

in Current Biology (2005), 15(18), 1629-39

Top of Page

2004

See detailJanus kinase (Jak) subcellular localization revisited: the exclusive membrane localization of endogenous Janus kinase 1 by cytokine receptor interaction uncovers the Jak.receptor complex to be equivalent to a receptor tyrosine kinase
Behrmann, Iris; Smyczek, Tanja; Heinrich, Peter C.; Schmitz-Van de Leur, Hildegard; Komyod, Waraporn; Giese, Bernd; Muller-Newen, Gerhard; Haan, Serge; Haan, Claude

in Journal of Biological Chemistry (2004), 279(34), 35486-93

See detailThe role of the inhibitors of interleukin-6 signal transduction SHP2 and SOCS3 for desensitization of interleukin-6 signalling
Fischer, P.; Lehmann, U.; Sobota, R. M.; Schmitz, J.; Niemand, C.; Linnemann, S.; Haan, Serge; Behrmann, Iris; Yoshimura, A.; Johnston, J. A.; Müller-Newen, G.; Heinrich, P. C.; Schaper, F.

in Biochemical Journal (2004), 378(Pt 2), 449-60

See detailInterferon-gamma-mediated growth regulation of melanoma cells: involvement of STAT1-dependent and STAT1-independent signals
Kortylewski, M.; Komyod, W.; Kauffmann, M. E.; Bosserhoff, A. K.; Heinrich, P. C.; Behrmann, Iris

in Journal of Investigative Dermatology (2004), 122(2), 414-22

Top of Page

2003

See detailCharacterization of methylthioadenosin phosphorylase (MTAP) expression in malignant melanoma
Behrmann, Iris; Wallner, S.; Komyod, W.; Heinrich, P. C.; Schuierer, M.; Buettner, R.; Bosserhoff, A. K.

in American Journal of Pathology (2003), 163(2), 683-90

See detailLong term association of the cytokine receptor gp130 and the Janus kinase Jak1 revealed by FRAP analysis
Giese, B.; Au-Yeung, C. K.; Herrmann, A.; Diefenbach, S.; Haan, Claude; Küster, A.; Wortmann, S. B.; Roderburg, C.; Heinrich, P. C.; Behrmann, Iris; Müller-Newen, G.

in Journal of Biological Chemistry (2003), 278(40), 39205-13

See detailPrinciples of interleukin (IL)-6-type cytokine signalling and its regulation
Heinrich, P. C.; Behrmann, Iris; Haan, Serge; Hermanns, H. M.; Müller-Newen, G.; Schaper, F.

in Biochemical Journal (2003), 374(Pt 1), 1-20

See detailAkt modulates STAT3-mediated gene expression through a FKHR (FOXO1a)-dependent mechanism
Kortylewski, M.; Feld, F.; Krüger, K. D.; Bahrenberg, G.; Roth, R. A.; Joost, H. G.; Heinrich, P. C.; Behrmann, Iris; Barthel, A.

in Journal of Biological Chemistry (2003), 278(7), 5242-9

Top of Page

2002

See detailIdentification of the critical sequence elements in the cytoplasmic domain of leptin receptor isoforms required for Janus kinase/signal transducer and activator of transcription activation by receptor heterodimers
Bahrenberg, G.; Behrmann, Iris; Barthel, A.; Hekerman, P.; Heinrich, P. C.; Joost, H. G.; Becker, Werner

in Molecular Endocrinology (2002), 16(4), 859-72

See detailOrientational constraints of the gp130 intracellular juxtamembrane domain for signaling
Greiser, J. S.; Stross, C.; Heinrich, P. C.; Behrmann, Iris; Hermanns, H. M.

in Journal of Biological Chemistry (2002), 277(30), 26959-65

See detailSHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130
Lehmann, U.; Schmitz, J.; Weissenbach, M.; Sobota, R. M.; Hortner, M.; Friederichs, K.; Behrmann, Iris; Tsiaris, W.; Sasaki, A.; Schneider-Mergener, J.; Yoshimura, A.; Neel, B. G.; Heinrich, P. C.; Schaper, F.

in Journal of Biological Chemistry (2002), 278(1), 661-71

See detailNovel role of Janus kinase 1 in the regulation of oncostatin M receptor surface expression
Radtke, S.; Hermanns, H. M.; Haan, Claude; Schmitz-Van De Leur, H.; Gascan, H.; Heinrich, P. C.; Behrmann, Iris

in Journal of Biological Chemistry (2002), 277(13), 11297-305

See detailThe matrix metalloproteinase 9 (mmp-9) hemopexin domain is a novel gelatin binding domain and acts as an antagonist
Roeb, E.; Schleinkofer, K.; Kernebeck, T.; Pötsch, S.; Jansen, B.; Behrmann, Iris; Matern, S.; Grötzinger, J.

in Journal of Biological Chemistry (2002), 277(52), 50326-32

Top of Page

2001

See detailInterleukin-6-resistant melanoma cells exhibit reduced activation of STAT3 and lack of inhibition of cyclin E-associated kinase activity
Böhm, M.; Schulte, U.; Funk, J. O.; Raghunath, M.; Behrmann, Iris; Kortylewski, M.; Heinrich, P. C.; Kues, T.; Luger, T. A.; Schwarz, T.

in Journal of Investigative Dermatology (2001), 117(1), 132-40

See detailMapping of a region within the N terminus of Jak1 involved in cytokine receptor interaction
Haan, Claude; Isharc, H.; Hermanns, H. M.; Schmitz-Van De Leur, H.; Kerr, I. M.; Heinrich, P. C.; Grötzinger, J.; Behrmann, Iris

in Journal of Biological Chemistry (2001), 276(40), 37451-8

See detailNon-redundant signal transduction of interleukin-6-type cytokines. The adapter protein Shc is specifically recruited to rhe oncostatin M receptor
Hermanns, H. M.; Radtke, S.; Schaper, F.; Heinrich, P. C.; Behrmann, Iris

in Journal of Biological Chemistry (2001), 275(52), 40742-8

See detailA region encompassing the FERM domain of Jak1 is necessary for binding to the cytokine receptor gp130
Hilkens, C. M.; Isharc, H.; Lillemeier, B. F.; Strobl, B.; Bates, P. A.; Behrmann, Iris; Kerr, I. M.

in FEBS Letters (2001), 505(1), 87-91

See detailMitogen-activated protein kinases control p27/Kip1 expression and growth of human melanoma cells
Kortylewski, M.; Heinrich, P. C.; Kauffmann, M. E.; Böhm, M.; MacKiewicz, A.; Behrmann, Iris

in Biochemical Journal (2001), 357(Pt 1), 297-303

See detailCytokine-mediated growth inhibition of human melanoma cells
Kortylewski, M.; Heinrich, P. C.; Mackiewicz, A.; Behrmann, Iris

in Advances in Experimental Medicine and Biology (2001), 495

See detailSTAT3 is constitutively activated in Hodgkin cell lines
Kube, D.; Holtick, U.; Vockerodt, M.; Ahmadi, T.; Haier, B.; Behrmann, Iris; Heinrich, P. C.; Diehl, V.; Tesch, H.

in Blood (2001), 98(3), 762-70

See detailA completely foreign receptor can mediate an interferon-gamma-like response
Strobl, B.; Arulampalam, V.; Isharc, H.; Newman, S. J.; Schlaak, J. F.; Watling, D.; Costa-Pereira, A. P.; Schaper, F.; Behrmann, Iris; Sheehan, K. C.; Schreiber, R. D.; Horn, F.; Heinrich, P. C.; Kerr, I. M.

in EMBO Journal (2001), 20(19), 5431-42

See detailNeutralizing monoclonal antibodies can potentiate IL-5 signaling
Zabeau, L.; Van der Heyden, J.; Broekaert, D.; Verhee, A.; Vandekerckhove, J.; Wu, S. J.; Chaiken, I.; Heinrich, P.; Behrmann, Iris; Tavernier, J.

in European Journal of Immunology (2001), 31(4), 1087-97

Top of Page

2000

See detailSignal transduction of IL-6, leukemia-inhibitory factor, and oncostatin M: structural receptor requirements for signal attenuation
Anhuf, D.; Weissenbach, M.; Schmitz, J.; Sobota, R.; Hermanns, H. M.; Radtke, S.; Linnemann, S.; Behrmann, Iris; Heinrich, P. C.; Schaper, F.

in Journal of Immunology (2000), 165(5), 2535-43

See detailSignalling of interleukin-6 type cytokines via gp130, leukemia inhibitory factor (LIF) receptor and oncostatin M receptor
Behrmann, Iris; Hermanns, H. M.; Haan, Claude; Kortylewski, M.; Radtke, S.; Greiser, J. S.; Heinrich, P. C.

in European Cytokine Network (2000), 11(3), 491-2

See detailCytoplasmic STAT proteins associate prior to activation
Haan, Serge; Kortylewski, M.; Behrmann, Iris; Müller-Esterl, W.; Heinrich, P. C.; Schaper, F.

in Biochemical Journal (2000), 345 Pt 3

See detailContributions of leukemia inhibitory factor receptor and oncostatin M receptor to signal transduction in heterodimeric complexes with glycoprotein 130
Hermanns, H. M.; Radtke, S.; Haan, Claude; Schmitz-Van de Leur, H.; Tavernier, J.; Heinrich, P. C.; Behrmann, Iris

in Journal of Immunology (2000), 163(12), 6651-8

See detailAn MMP-9 mutant without gelatinolytic activity as a novel TIMP-1-antagonist
Roeb, E.; Behrmann, Iris; Grötzinger, J.; Breuer, B.; Matern, S.

in FASEB Journal (2000), 14(12), 1671-3

See detailDifferential inhibition of IL-6-type cytokine-induced STAT activation by PMA
Terstegen, L.; Maassen, B. G.; Radtke, S.; Behrmann, Iris; Schaper, F.; Heinrich, P. C.; Graeve, L.; Gatsios, P.

in FEBS Letters (2000), 478(1-2), 100-4

See detailTermination of IL-6-induced STAT activation is independent of receptor internalization but requires de novo protein synthesis
Thiel, S.; Sommer, U.; Kortylewski, M.; Haan, Claude; Behrmann, Iris; Heinrich, P. C.; Graeve, L.

in FEBS Letters (2000), 470(1), 15-9

Top of Page

1999

See detailInterleukin-6 and oncostatin M-induced growth inhibition of human A375 melanoma cells is STAT-dependent and involves upregulation of the cyclin-dependent kinase inhibitor p27/Kip1
Kortylewski, M.; Heinrich, P. C.; Mackiewicz, A.; Schniertshauer, U.; Klingmüller, U.; Nakajima, K.; Hirano, T.; Horn, F.; Behrmann, Iris

in Oncogene (1999), 18(25), 3742-53

See detailIdentification of a Leu-lle internalization motif within the cytoplasmic domain of the leukaemia inhibitory factor receptor
Thiel, S.; Behrmann, Iris; Timmermann, A.; Dahmen, H.; Müller-Newen, G.; Schaper, F.; Tavernier, J.; Pitard, V.; Heinrich, P. C.; Graeve, L.

in Biochemical Journal (1999), 339 (Pt 1)

Top of Page

1998

See detailInterleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway
Heinrich, P. C.; Behrmann, Iris; Müller-Newen, G.; Schaper, F.; Graeve, L.

in Biochemical Journal (1998), 334 (Pt 2)

See detailInternalization of the interleukin 6 signal transducer gp130 does not require activation of the Jak/STAT pathway
Thiel, S.; Behrmann, Iris; Dittrich, E.; Muys, L.; Tavernier, J.; Wijdenes, J.; Heinrich, P. C.; Graeve, L.

in Biochemical Journal (1998), 330 (Pt 1)

Top of Page

1997

See detailA single STAT recruitment module in a chimeric cytokine receptor complex is sufficient for STAT activation
Behrmann, Iris; Janzen, C.; Gerhartz, C.; Schmitz-Van de Leur, H.; Hermanns, H.; Heesel, B.; Graeve, L.; Horn, F.; Tavernier, J.; Heinrich, P. C.

in Journal of Biological Chemistry (1997), 272(8), 5269-74

Top of Page

1996

See detailCytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor
Kischkel, F. C.; Hellbardt, S.; Behrmann, Iris; Germer, M.; Pawlita, M.; Krammer, P. H.; Peter, M. E.

in EMBO Journal (1996), 14(22), 5579-88

Top of Page

1995

See detailStructure of the human APO-1 gene
Behrmann, Iris; Walczak, H.; Krammer, P. H.

in European Journal of Immunology (1995), 24(12), 3057-62

See detailAPO-I-mediated apoptosis in normal and malignant lymphocytes
Dhein, J.; Behrmann, Iris; Daniel, P. T.; Debatin, K. M.; Klas, C.; Möller, P.; Oehm, A.; Trauth, B. C.; Walczak, H.; Krammer, P. H.

in Biochemical Society Transactions (1995), 22(3), 598-600

See detailThe role of APO-1-mediated apoptosis in the immune system
Krammer, P. H.; Dhein, J.; Walczak, H.; Behrmann, Iris; Mariani, S.; Matiba, B.; Fath, M.; Daniel, P. T.; Knipping, E.; Westendorp, M. O.

in Immunological Reviews (1995), 142

Top of Page

1994

See detailRegulation of apoptosis in the immune system
Krammer, P. H.; Behrmann, Iris; Daniel, P. T.; Dhein, J.; Debatin, K. M.

in Current Opinion in Immunology (1994), 6(2), 279-89

Top of Page

1992

See detailPurification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily. Sequence identity with the Fas antigen
Oehm, A.; Behrmann, Iris; Falk, W.; Pawlita, M.; Maier, G.; Klas, C.; Li-Weber, M.; Richards, S.; Dhein, J.; Trauth, B. C.

in Journal of Biological Chemistry (1992), 267(15), 10709-15

Top of Page

1990

Top of Page